RT Journal Article SR Electronic T1 Double blind trial of clonidine in the treatment of migraine in a general practice JF The Journal of the Royal College of General Practitioners JO J R Coll Gen Pract FD British Journal of General Practice SP 587 OP 590 VO 28 IS 195 A1 E. I. Adam A1 Sheila M. Gore A1 W. H. Price YR 1978 UL http://bjgp.org/content/28/195/587.abstract AB The value of clonidine (`Dixarit') for the prophylaxis of migraine has been assessed by a double blind cross-over trial. A dose of up to 0·15 mg daily was used. No effect on the frequency of the headaches could be detected over and above the 60 per cent reduction observed with a placebo. Severity, assessed subjectively by the patient, when it varied between placebo and clonidine, was less with clonidine (p<0·01). There was also some evidence that headaches lasting more than 12 hours were less common during treatment with the drug.