PT - JOURNAL ARTICLE AU - A P Hungin AU - G Rubin AU - H O'Flanagan TI - Factors influencing compliance in long-term proton pump inhibitor therapy in general practice. DP - 1999 Jun 01 TA - British Journal of General Practice PG - 463--464 VI - 49 IP - 443 4099 - http://bjgp.org/content/49/443/463.short 4100 - http://bjgp.org/content/49/443/463.full SO - Br J Gen Pract1999 Jun 01; 49 AB - Long-term proton pump inhibitor (PPI) prescribing in general practice is common, but only a minority of patients request their prescriptions regularly. This study determined factors linked with compliance using questionnaires and diary cards. The chief factors determining whether or not patients took their PPIs were the presence or severity of symptoms and the desire to remain in personal control, together with a fear of side-effects and lack of knowledge about the drugs. As most such prescribing is for uncomplicated gastro-oesophageal reflux disease, on-demand therapy should now be formally advocated.