PT - JOURNAL ARTICLE AU - Morten Lindbæk AU - Ernst Arne Høiby AU - Gro Lermark AU - Inger Marie Steinsholt AU - Per Hjortdahl TI - Clinical symptoms and signs in sore throat patients with large colony variant β-haemolytic streptococci groups C or G versus group A DP - 2005 Aug 01 TA - British Journal of General Practice PG - 615--619 VI - 55 IP - 517 4099 - http://bjgp.org/content/55/517/615.short 4100 - http://bjgp.org/content/55/517/615.full SO - Br J Gen Pract2005 Aug 01; 55 AB - Background The role of large colony streptococci groups C or G as pathogen agents in sore throat has been questioned.Aim To analyse clinical features of patients with large colony streptococci groups C or G compared with patients with group A streptococci (GAS) and with negative cultures.Design of study Prospective study of patients with sore throat.Setting Two Norwegian general practices in Stokke and Kongsberg communities with 6500 patients.Method Frequency of clinical features in the three patient categories including the four Centor criteria (fever, anterior cervical lymphadenopathy, tonsillar exudates, and lack of cough), degree of pain on swallowing, pharyngeal rubor, C-reactive protein (CRP) values, patient age between 3 and 14 years, and duration of symptoms before seeing the doctor. A logistic regression analysis to find independent predictors was performed.Results Out of 306 patients with a sore throat, 244 were adults and 62 were children under 10 years old; 40% were men. One hundred and twenty-seven had GAS, 33 had streptococci groups C or G, and 146 had negative throat cultures. Forty-eight per cent of the GAS patients and 45% of the C or G patients met three or four of the Centor criteria. The logistic regression revealed that in patients with GAS considerable pain on swallowing, an age of 3–14 years and a duration of symptoms of ≤3 days or less were significantly associated with GAS infection in addition to the Centor criteria. The same results were found when all streptococci were analysed together, in addition elevated CRP was significant. In patients with streptococci group C or G an elevated CRP-value was significantly associated.Conclusion Patients with tonsillitis caused by streptococcus groups C or G have, to a large extent, the same clinical picture as patients with GAS. Large colony streptococci groups C and G should be considered as throat pathogens in line with GAS.