RT Journal Article
SR Electronic
T1 Hepatitis C infection among injecting drug users in general practice: a cluster randomised controlled trial of clinical guidelines' implementation
JF British Journal of General Practice
JO Br J Gen Pract
FD British Journal of General Practice
SP 848
OP 856
VO 56
IS 532
A1 Walter Cullen
A1 June Stanley
A1 Deirdre Langton
A1 Yvonne Kelly
A1 Anthony Staines
A1 Gerard Bury
YR 2006
UL http://bjgp.org/content/56/532/848.abstract
AB Background Hepatitis C is a common infection among injecting drug users and has important implications for general practice. Although several clinical guidelines concerning the infection have been published, their effectiveness has yet to be tested.Aim To assess the effectiveness of a general practice-based complex intervention to support the implementation of clinical guidelines for hepatitis C management among current or former drug users attending general practice.Design of study Cluster randomised controlled trial.Setting General practices in the Eastern Regional Health Authority area of Ireland.Method Twenty-six practices were randomly allocated within strata to receive the intervention under study or to provide care as usual for a period of 6 months. There was screening for patients attending general practice for methadone maintenance treatment for hepatitis C and referral of anti-HCV antibody positive patients to a specialist hepatology department for assessment.Results At study completion, patients in the intervention group were significantly more likely to have been screened for hepatitis C than those in the control group, odds ratio adjusted for clustering 3.76 (95% confidence interval [CI] = 1.3 to 11.3) and this association remained significant after adjusting for other potentially confounding variables, using multiple logistic regression, with the odds ratio adjusted for clustering 4.53 (95% CI = 1.39 to 14.78). Although anti-HCV antibody positive patients in the intervention group were more likely to have been referred to a hepatology clinic, this was not statistically significant (P = 0.06).Conclusion General practice has an important role in the care of people at risk of hepatitis C and when appropriately supported can effectively implement current best practice.