TY - JOUR T1 - NICE guidelines on antidepressants JF - British Journal of General Practice JO - Br J Gen Pract SP - 798 LP - 798 VL - 56 IS - 531 AU - R. Hamish McAllister-Williams AU - Karin Foran AU - Steven Forrest AU - Graham Ingram AU - Lindsay McMahon AU - Michelle Taylor AU - Madhuri Rajwal AU - Lenny Cornwall Y1 - 2006/10/01 UR - http://bjgp.org/content/56/531/798.2.abstract N2 - In December 2004 NICE issued clinical guidelines regarding depression. These included restrictions on venlafaxine with baseline ECGs and prescribing by specialists only recommended. This was based on unpublished data regarding the cardiac effects of the drug and concerns of toxicity in overdose.On 31 May 2006, MHRA released a statement following an appeal against the restrictions by the manufacturer, Wyeth. This conceded that baseline ECGs are unnecessary for most patients. Further, MHRA accepted data showing that venlafaxine is more … ER -