RT Journal Article
SR Electronic
T1 Isotretinoin, depression and suicide: a review of the evidence
JF British Journal of General Practice
JO Br J Gen Pract
FD British Journal of General Practice
SP 134
OP 138
VO 55
IS 511
A1 Parker Magin
A1 Dimity Pond
A1 Wayne Smith
YR 2005
UL http://bjgp.org/content/55/511/134.abstract
AB There is currently considerable controversy regarding a proposed causal relationship between the use of isotretinoin and depression and suicide. A search was made of the MEDLINE, EMBASE and PsychINFO databases using the search terms ‘isotretinoin’, ‘depression’ and ‘suicide’. Despite numerous case reports linking isotretinoin to depression, suicidal ideation and suicide, there is, as yet, no clear proof of an association. While isotretinoin, used to treat acne vulgaris, has not been demonstrated to be associated with depression or suicide, the possibility of a relatively rare idiosyncratic adverse effect remains. GPs have a role in the clinical application of these findings.