TY - JOUR T1 - Managing hyperglycaemia JF - British Journal of General Practice JO - Br J Gen Pract SP - 729 LP - 729 DO - 10.3399/bjgp08X342408 VL - 58 IS - 555 AU - Simon Curtis Y1 - 2008/10/01 UR - http://bjgp.org/content/58/555/729.2.abstract N2 - Drs Munro and Feher provide an interesting, useful overview of glucose metabolism and emerging therapies for managing hyperglycaemia in their recent editorial.1 However, the elephant in the room they fail to discuss is this: in an asymptomatic patient, how clinically worthwhile is reducing a surrogate marker such as HbAIc?They state that the recent ACCORD and ADVANCE studies ‘show microvascular benefit’ from intensive glucose reduction and conclude that ‘glucose lowering in type 2 diabetes continues to show clear benefits’. But, just what are these benefits? The ACCORD2 study did not report … ER -