TY - JOUR T1 - Benzodiazepine tolerance, dependency, and withdrawal syndromes and interactions with fluoroquinolone antimicrobials JF - British Journal of General Practice JO - Br J Gen Pract SP - 365 LP - 366 DO - 10.3399/bjgp08X280317 VL - 58 IS - 550 AU - John Girvan McConnell Y1 - 2008/05/01 UR - http://bjgp.org/content/58/550/365.2.abstract N2 - I investigated reports of an abnormally high incidence of adverse reactions to fluoroquinolone antibiotics in patients dependent on and withdrawing from benzodiazepines. Participants of an online benzodiazepine withdrawal support group (www.thetrap.org.uk) who reported fluoroquinolone use were asked to fill out a structured questionnaire. Eleven participants reported severe or very severe adverse reactions, one participant reported a moderate adverse reaction, and a further participant reported no reaction to fluoroquinolone treatment. In most cases adverse symptoms resolved within 1 month of cessation of fluoroquinolone dosing. However, in some … ER -