RT Journal Article SR Electronic T1 Feasibility and indicative results from a 12-month low-energy liquid diet treatment and maintenance programme for severe obesity JF British Journal of General Practice JO Br J Gen Pract FD British Journal of General Practice SP e115 OP e124 DO 10.3399/bjgp13X663073 VO 63 IS 607 A1 Michael Lean A1 Naomi Brosnahan A1 Philip McLoone A1 Louise McCombie A1 Anna Bell Higgs A1 Hazel Ross A1 Mhairi Mackenzie A1 Eleanor Grieve A1 Nick Finer A1 John Reckless A1 David Haslam A1 Billy Sloan A1 David Morrison YR 2013 UL http://bjgp.org/content/63/607/e115.abstract AB Background There is no established primary care solution for the rapidly increasing numbers of severely obese people with body mass index (BMI) > 40 kg/m2.Aim This programme aimed to generate weight losses of ≥15 kg at 12 months, within routine primary care.Design and setting Feasibility study in primary care.Method Patients with a BMI ≥40 kg/m2 commenced a micronutrient-replete 810–833 kcal/day low-energy liquid diet (LELD), delivered in primary care, for a planned 12 weeks or 20 kg weight loss (whichever was the sooner), with structured food reintroduction and then weight-loss maintenance, with optional orlistat to 12 months.Result Of 91 patients (74 females) entering the programme (baseline: weight 131 kg, BMI 48 kg/m2, age 46 years), 58/91(64%) completed the LELD stage, with a mean duration of 14.4 weeks (standard deviation [SD] = 6.0 weeks), and a mean weight loss of 16.9 kg (SD = 6.0 kg). Four patients commenced weight-loss maintenance omitting the food-reintroduction stage. Of the remaining 54, 37(68%) started and completed food reintroduction over a mean duration of 9.3 weeks (SD = 5.7 weeks), with a further mean weight loss of 2.1 kg (SD = 3.7 kg), before starting a long-term low-fat-diet weight-loss maintenance plan. A total of 44/91 (48%) received orlistat at some stage. At 12 months, weight was recorded for 68/91 (75%) patients, with a mean loss of 12.4 kg (SD = 11.4 kg). Of these, 30 (33% of all 91 patients starting the programme) had a documented maintained weight loss of ≥15 kg at 12 months, six (7%) had a 10–15 kg loss, and 11 (12%) had a 5–10 kg loss. The indicative cost of providing this entire programme for wider implementation would be £861 per patient entered, or £2611 per documented 15 kg loss achieved.Conclusion A care package within routine primary care for severe obesity, including LELD, food reintroduction, and weight-loss maintenance, was well accepted and achieved a 12-month-maintained weight loss of ≥15 kg for one-third of all patients entering the programme.