TY - JOUR T1 - Benefits and harms of selective oestrogen receptor modulators (SERMs) to reduce breast cancer risk: a cross-sectional study of methods to communicate risk in primary care JF - British Journal of General Practice JO - Br J Gen Pract SP - e836 LP - e842 DO - 10.3399/bjgp19X706841 VL - 69 IS - 689 AU - Jennifer G McIntosh AU - Jesse Minshall AU - Sibel Saya AU - Adrian Bickerstaffe AU - Nadira Hewabandu AU - Ashleigh Qama AU - Jon D Emery Y1 - 2019/12/01 UR - http://bjgp.org/content/69/689/e836.abstract N2 - Background In Australia, evidence-based guidelines recommend that women consider taking selective oestrogen receptor modulators (SERMs) to reduce their risk of breast cancer. In practice, this requires effective methods for communicating the harms and benefits of taking SERMs so women can make an informed choice.Aim To evaluate how different risk presentations influence women’s decisions to consider taking SERMs.Design and setting Cross-sectional, correlational study of Australian women in general practice.Method Three risk communication formats were developed that included graphics, numbers, and text to explain the reduction in breast cancer risk and risk of side effects for women taking SERMs (raloxifene or tamoxifen). Women aged 40–74 years in two general practices were shown the risk formats using vignettes of hypothetical women at moderate or high risk of breast cancer and asked to choose ‘If this was you, would you consider taking a SERM?’ Descriptive statistics and predictors (risk format, level of risk, and type of SERM) of choosing SERMs were determined by logistic regression.Results A total of 288 women were recruited (an 88% response rate) between March and May 2017. The risk formats that showed a government statement and an icon array were associated with a greater likelihood of considering SERMs relative to one that showed a novel expected frequency tree. Risk formats for raloxifene and for the high-risk vignettes were also more strongly associated with choosing to consider SERMs. No associations were found with any patient demographics.Conclusion Specific risk formats may lead to more women considering taking SERMs to reduce breast cancer risk, especially if they are at high risk of the condition. Raloxifene may be a more acceptable SERM to patients. ER -