PT  - JOURNAL ARTICLE
AU  - Patricia Moreno-Peral
AU  - Sonia Conejo-Cerón
AU  - Juan de Dios Luna
AU  - Michael King
AU  - Irwin Nazareth
AU  - Carlos Martín-Pérez
AU  - Carmen Fernández-Alonso
AU  - María Isabel Ballesta-Rodríguez
AU  - Anna Fernández
AU  - José María Aiarzaguena
AU  - Carmen Montón-Franco
AU  - Juan Ángel Bellón
ED  - ,
TI  - Use of a personalised depression intervention in primary care to prevent anxiety: a secondary study of a cluster randomised trial
AID  - 10.3399/bjgp20X714041
DP  - 2021 Feb 01
TA  - British Journal of General Practice
PG  - e95--e104
VI  - 71
IP  - 703
4099  - http://bjgp.org/content/71/703/e95.short
4100  - http://bjgp.org/content/71/703/e95.full
SO  - Br J Gen Pract2021 Feb 01; 71
AB  - Background In the predictD-intervention, GPs used a personalised biopsychosocial programme to prevent depression. This reduced the incidence of major depression by 21.0%, although the results were not statistically significant.Aim To determine whether the predictD-intervention is effective at preventing anxiety in primary care patients without depression or anxiety.Design and setting Secondary study of a cluster randomised trial with practices randomly assigned to either the predictD-intervention or usual care. This study was conducted in seven Spanish cities from October 2010 to July 2012.Method In each city, 10 practices and two GPs per practice, as well as four to six patients every recruiting day, were randomly selected until there were 26–27 eligible patients for each GP. The endpoint was cumulative incidence of anxiety as measured by the PRIME-MD screening tool over 18 months.Results A total of 3326 patients without depression and 140 GPs from 70 practices consented and were eligible to participate; 328 of these patients were removed because they had an anxiety syndrome at baseline. Of the 2998 valid patients, 2597 (86.6%) were evaluated at the end of the study. At 18 months, 10.4% (95% CI = 8.7% to 12.1%) of the patients in the predictD-intervention group developed anxiety compared with 13.1% (95% CI = 11.4% to 14.8%) in the usual-care group (absolute difference = −2.7% [95% CI = −5.1% to −0.3%]; P = 0.029).Conclusion A personalised intervention delivered by GPs for the prevention of depression provided a modest but statistically significant reduction in the incidence of anxiety.