TY - JOUR T1 - Diagnosing community-acquired pneumonia via a smartphone-based algorithm: a prospective cohort study in primary and acute-care consultations JF - British Journal of General Practice JO - Br J Gen Pract SP - e258 LP - e265 DO - 10.3399/BJGP.2020.0750 VL - 71 IS - 705 AU - Paul Porter AU - Joanna Brisbane AU - Udantha Abeyratne AU - Natasha Bear AU - Javan Wood AU - Vesa Peltonen AU - Phillip Della AU - Claire Smith AU - Scott Claxton Y1 - 2021/04/01 UR - http://bjgp.org/content/71/705/e258.abstract N2 - Background Community-acquired pneumonia (CAP) is an essential consideration in patients presenting to primary care with respiratory symptoms; however, accurate diagnosis is difficult when clinical and radiological examinations are not possible, such as during telehealth consultations.Aim To develop and test a smartphone-based algorithm for diagnosing CAP without need for clinical examination or radiological inputs.Design and setting A prospective cohort study using data from participants aged >12 years presenting with acute respiratory symptoms to a hospital in Western Australia.Method Five cough audio-segments were recorded and four patient-reported symptoms (fever, acute cough, productive cough, and age) were analysed by the smartphone-based algorithm to generate an immediate diagnostic output for CAP. Independent cohorts were recruited to train and test the accuracy of the algorithm. Diagnostic agreement was calculated against the confirmed discharge diagnosis of CAP by specialist physicians. Specialist radiologists reported medical imaging.Results The smartphone-based algorithm had high percentage agreement (PA) with the clinical diagnosis of CAP in the total cohort (n = 322, positive PA [PPA] = 86.2%, negative PA [NPA] = 86.5%, area under the receiver operating characteristic curve [AUC] = 0.95); in participants 22–<65 years (n = 192, PPA = 85.7%, NPA = 87.0%, AUC = 0.94), and in participants aged ≥65 years (n = 86, PPA = 85.7%, NPA = 87.5%, AUC = 0.94). Agreement was preserved across CAP severity: 85.1% (n = 80/94) of participants with CRB-65 scores 1 or 2, and 87.7% (n = 57/65) with a score of 0, were correctly diagnosed by the algorithm.Conclusion The algorithm provides rapid and accurate diagnosis of CAP. It offers improved accuracy over current protocols when clinical evaluation is difficult. It provides increased capabilities for primary and acute care, including telehealth services, required during the COVID-19 pandemic. ER -