%0 Journal Article %A Helen J Curtis %A Peter Inglesby %A Caroline E Morton %A Brian MacKenna %A Amelia Green %A William J Hulme %A Alex J Walker %A Jessica Morley %A Amir Mehrkar %A Seb Bacon %A George Hickman %A Chris Bates %A Richard Croker %A David Evans %A Tom Ward %A Jonathan Cockburn %A Simon Davy %A Krishnan Bhaskaran %A Anna Schultze %A Christopher T Rentsch %A Elizabeth J Williamson %A Anna Rowan %A Helen McDonald %A Louis Fisher %A Laurie Tomlinson %A Rohini Mathur %A Henry Drysdale %A Rosalind M Eggo %A Kevin Wing %A Angel YS Wong %A Harriet Forbes %A John Parry %A Frank Hester %A Sam Harper %A Shaun O'Hanlon %A Alex Eavis %A Richard Jarvis %A Dima Avramov %A Paul Griffiths %A Aaron Fowles %A Nasreen Parkes %A Ian Douglas %A Stephen JW Evans %A Liam Smeeth %A Ben Goldacre %T Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients’ primary care records in situ using OpenSAFELY %D 2021 %R 10.3399/BJGP.2021.0376 %J British Journal of General Practice %P BJGP.2021.0376 %X Background: On December 8th 2020 NHS England administered the first COVID-19 vaccination. Aim: Describe trends and variation in vaccine coverage by clinical and demographic groups. Design and Setting: With the approval of NHS England, we conducted a cohort study of 57.9 million patient records in general practice in England, in-situ and within the infrastructure of the Electronic Health Record (EHR) software vendors EMIS and TPP using OpenSAFELY. Method: We describe vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts. Results: 20,852,692 patients (36%) received a vaccine between December 8th and March 17th 2021. Of patients aged ≥80 not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2% vaccinated, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5% vaccinated) and learning disability (91.4%). 275,205 vaccine recipients were identified as care home residents (priority group 1; 91.2% coverage). 1,257,914 (6.0%) recipients have had a second dose. Detailed characteristics of all cohorts are reported. Conclusion: The NHS in England has rapidly delivered mass vaccination. We deployed a data monitoring framework using publicly auditable methods and a secure, in-situ processing model, using linked but pseudonymised patient-level NHS data on 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups. %U https://bjgp.org/content/bjgp/early/2021/09/24/BJGP.2021.0376.full.pdf