RT Journal Article
SR Electronic
T1 Predicting asthma-related crisis events using routine electronic healthcare data: a quantitative database analysis study
JF British Journal of General Practice
JO Br J Gen Pract
FD British Journal of General Practice
SP e948
OP e957
DO 10.3399/BJGP.2020.1042
VO 71
IS 713
A1 Michael Noble
A1 Annie Burden
A1 Susan Stirling
A1 Allan B Clark
A1 Stanley Musgrave
A1 Mohammad A Alsallakh
A1 David Price
A1 Gwyneth A Davies
A1 Hilary Pinnock
A1 Martin Pond
A1 Aziz Sheikh
A1 Erika J Sims
A1 Samantha Walker
A1 Andrew M Wilson
YR 2021
UL http://bjgp.org/content/71/713/e948.abstract
AB Background There is no published algorithm predicting asthma crisis events (accident and emergency [A&E] attendance, hospitalisation, or death) using routinely available electronic health record (EHR) data.Aim To develop an algorithm to identify individuals at high risk of an asthma crisis event.Design and setting Database analysis from primary care EHRs of people with asthma across England and Scotland.Method Multivariable logistic regression was applied to a dataset of 61 861 people with asthma from England and Scotland using the Clinical Practice Research Datalink. External validation was performed using the Secure Anonymised Information Linkage Databank of 174 240 patients from Wales. Outcomes were ≥1 hospitalisation (development dataset) and asthma-related hospitalisation, A&E attendance, or death (validation dataset) within a 12-month period.Results Risk factors for asthma-related crisis events included previous hospitalisation, older age, underweight, smoking, and blood eosinophilia. The prediction algorithm had acceptable predictive ability with a receiver operating characteristic of 0.71 (95% confidence interval [CI] = 0.70 to 0.72) in the validation dataset. Using a cut-point based on the 7% of the population at greatest risk results in a positive predictive value of 5.7% (95% CI = 5.3% to 6.1%) and a negative predictive value of 98.9% (95% CI = 98.9% to 99.0%), with sensitivity of 28.5% (95% CI = 26.7% to 30.3%) and specificity of 93.3% (95% CI = 93.2% to 93.4%); those individuals had an event risk of 6.0% compared with 1.1% for the remaining population. In total, 18 people would need to be followed to identify one admission.Conclusion This externally validated algorithm has acceptable predictive ability for identifying patients at high risk of asthma-related crisis events and excluding those not at high risk.