TY - JOUR T1 - Non-speculum sampling approaches for cervical screening in older women: randomised controlled trial JF - British Journal of General Practice JO - Br J Gen Pract SP - e26 LP - e33 DO - 10.3399/BJGP.2021.0350 VL - 72 IS - 714 AU - Rebecca Landy AU - Tony Hollingworth AU - Jo Waller AU - Laura AV Marlow AU - Jane Rigney AU - Thomas Round AU - Peter D Sasieni AU - Anita WW Lim Y1 - 2022/01/01 UR - http://bjgp.org/content/72/714/e26.abstract N2 - Background Cervical cancer disproportionately affects women ≥65 years, especially those not screened regularly. Speculum use is a key barrier.Aim To assess if offering non-speculum clinician-taken sampling and self-sampling increases uptake for lapsed attenders aged 50–64 years.Design and setting Pragmatic randomised control trial conducted at 10 general practices in East London, UK.Method Participants were 784 women aged 50–64 years, last screened 6–15 years before randomisation. Intervention participants received a letter offering the choice of non-speculum clinician- or self-sampling. Control participants received usual care. The main outcome measure was uptake within 4 months.Results Screening uptake 4 months after randomisation was significantly higher in the intervention arm: 20.4% (n = 80/393) versus 4.9% in the control arm (n = 19/391, absolute difference 15.5%, 95% confidence interval [CI] = 11.0% to 20.0%, P<0.001). This was maintained at 12 months: intervention 30.5% (n = 120/393) versus control 13.6% (n = 53/391) (absolute difference 17.0%, 95% CI = 11.3% to 22.7%, P<0.001). Conventional screening attendance within 12 months was very similar for both intervention 12.7% (n = 50/393) and control 13.6% (n = 53/391) arms. Ethnic differences were seen in screening modality preference. More White women opted for self-sampling (50.7%, n = 38/75), whereas most Asian and Black women and those from other ethnic backgrounds opted for conventional screening.Conclusion Offering non-speculum clinician-taken sampling and self-sampling substantially increases uptake in older lapsed attendee women. Non-speculum clinician sampling appeals to women who dislike the speculum but still prefer a clinician to take their sample. Providing a choice of screening modality may be important for optimising cervical screening uptake. ER -