TY - JOUR T1 - Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients' primary care records <em>in situ</em> using OpenSAFELY JF - British Journal of General Practice JO - Br J Gen Pract SP - e51 LP - e62 DO - 10.3399/BJGP.2021.0376 VL - 72 IS - 714 AU - Helen J Curtis AU - Peter Inglesby AU - Caroline E Morton AU - Brian MacKenna AU - Amelia Green AU - William Hulme AU - Alex J Walker AU - Jessica Morley AU - Amir Mehrkar AU - Seb Bacon AU - George Hickman AU - Chris Bates AU - Richard Croker AU - David Evans AU - Tom Ward AU - Jonathan Cockburn AU - Simon Davy AU - Krishnan Bhaskaran AU - Anna Schultze AU - Christopher T Rentsch AU - Elizabeth J Williamson AU - Anna Rowan AU - Louis Fisher AU - Helen I McDonald AU - Laurie Tomlinson AU - Rohini Mathur AU - Henry Drysdale AU - Rosalind M Eggo AU - Kevin Wing AU - Angel YS Wong AU - Harriet Forbes AU - John Parry AU - Frank Hester AU - Sam Harper AU - Shaun O’Hanlon AU - Alex Eavis AU - Richard Jarvis AU - Dima Avramov AU - Paul Griffiths AU - Aaron Fowles AU - Nasreen Parkes AU - Ian J Douglas AU - Stephen JW Evans AU - Liam Smeeth AU - Ben Goldacre AU - (The OpenSAFELY Collaborative) Y1 - 2022/01/01 UR - http://bjgp.org/content/72/714/e51.abstract N2 - Background On 8 December 2020 NHS England administered the first COVID-19 vaccination.Aim To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout.Design and setting With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY.Method Vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts is described.Results A total of 20 852 692 patients (36.0%) received a vaccine between 8 December 2020 and 17 March 2021. Of patients aged ≥80 years not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2%, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5%) and learning disability (91.4%). There were 275 205 vaccine recipients who were identified as care home residents (JCVI group 1; 91.2% coverage). By 17 March, 1 257 914 (6.0%) recipients had a second dose.Conclusion The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure in situ processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups. ER -