RT Journal Article
SR Electronic
T1 Trends and clinical characteristics of COVID-19 vaccine recipients: a federated analysis of 57.9 million patients' primary care records <em>in situ</em> using OpenSAFELY
JF British Journal of General Practice
JO Br J Gen Pract
FD British Journal of General Practice
SP e51
OP e62
DO 10.3399/BJGP.2021.0376
VO 72
IS 714
A1 Helen J Curtis
A1 Peter Inglesby
A1 Caroline E Morton
A1 Brian MacKenna
A1 Amelia Green
A1 William Hulme
A1 Alex J Walker
A1 Jessica Morley
A1 Amir Mehrkar
A1 Seb Bacon
A1 George Hickman
A1 Chris Bates
A1 Richard Croker
A1 David Evans
A1 Tom Ward
A1 Jonathan Cockburn
A1 Simon Davy
A1 Krishnan Bhaskaran
A1 Anna Schultze
A1 Christopher T Rentsch
A1 Elizabeth J Williamson
A1 Anna Rowan
A1 Louis Fisher
A1 Helen I McDonald
A1 Laurie Tomlinson
A1 Rohini Mathur
A1 Henry Drysdale
A1 Rosalind M Eggo
A1 Kevin Wing
A1 Angel YS Wong
A1 Harriet Forbes
A1 John Parry
A1 Frank Hester
A1 Sam Harper
A1 Shaun O’Hanlon
A1 Alex Eavis
A1 Richard Jarvis
A1 Dima Avramov
A1 Paul Griffiths
A1 Aaron Fowles
A1 Nasreen Parkes
A1 Ian J Douglas
A1 Stephen JW Evans
A1 Liam Smeeth
A1 Ben Goldacre
A1 (The OpenSAFELY Collaborative)
YR 2022
UL http://bjgp.org/content/72/714/e51.abstract
AB Background On 8 December 2020 NHS England administered the first COVID-19 vaccination.Aim To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout.Design and setting With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY.Method Vaccine coverage across various subgroups of Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts is described.Results A total of 20 852 692 patients (36.0%) received a vaccine between 8 December 2020 and 17 March 2021. Of patients aged ≥80 years not in a care home (JCVI group 2) 94.7% received a vaccine, but with substantial variation by ethnicity (White 96.2%, Black 68.3%) and deprivation (least deprived 96.6%, most deprived 90.7%). Patients with pre-existing medical conditions were more likely to be vaccinated with two exceptions: severe mental illness (89.5%) and learning disability (91.4%). There were 275 205 vaccine recipients who were identified as care home residents (JCVI group 1; 91.2% coverage). By 17 March, 1 257 914 (6.0%) recipients had a second dose.Conclusion The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure in situ processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups.