PT - JOURNAL ARTICLE AU - Daniel Jones AU - Erica Di Martino AU - Stephen H Bradley AU - Blessing Essang AU - Scott Hemphill AU - Judy M Wright AU - Cristina Renzi AU - Claire Surr AU - Andrew Clegg AU - Niek De Wit AU - Richard Neal TI - Factors affecting the decision to investigate older adults with potential cancer symptoms: a systematic review AID - 10.3399/BJGP.2021.0257 DP - 2022 Jan 01 TA - British Journal of General Practice PG - e1--e10 VI - 72 IP - 714 4099 - http://bjgp.org/content/72/714/e1.short 4100 - http://bjgp.org/content/72/714/e1.full SO - Br J Gen Pract2022 Jan 01; 72 AB - Background Older age and frailty increase the risk of morbidity and mortality from cancer surgery and intolerance of chemotherapy and radiotherapy. The effect of old age on diagnostic intervals is unknown; however, older adults need a balanced approach to the diagnosis and management of cancer symptoms, considering the benefits of early diagnosis, patient preferences, and the likely prognosis of a cancer.Aim To examine the association between older age and diagnostic processes for cancer, and the specific factors that affect diagnosis.Design and setting A systematic literature review.Method Electronic databases were searched for studies of patients aged >65 years presenting with cancer symptoms to primary care considering diagnostic decisions. Studies were analysed using thematic synthesis and according to the Synthesis Without Meta-analysis guidelines.Results Data from 54 studies with 230 729 participants were included. The majority of studies suggested an association between increasing age and prolonged diagnostic interval or deferral of a decision to investigate cancer symptoms. Thematic synthesis highlighted three important factors that resulted in uncertainty in decisions involving older adults: presence of frailty, comorbidities, and cognitive impairment. Data suggested patients wished to be involved in decision making, but the presence of cognitive impairment and the need for additional time within a consultation were significant barriers.Conclusion This systematic review has highlighted uncertainty in the management of older adults with cancer symptoms. Patients and their family wished to be involved in these decisions. Given the uncertainty regarding optimum management of this group of patients, a shared decision-making approach is important.