<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Landy, Rebecca</style></author><author><style face="normal" font="default" size="100%">Hollingworth, Tony</style></author><author><style face="normal" font="default" size="100%">Waller, Jo</style></author><author><style face="normal" font="default" size="100%">Marlow, Laura AV</style></author><author><style face="normal" font="default" size="100%">Rigney, Jane</style></author><author><style face="normal" font="default" size="100%">Round, Thomas</style></author><author><style face="normal" font="default" size="100%">Sasieni, Peter D</style></author><author><style face="normal" font="default" size="100%">Lim, Anita WW</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Non-speculum clinician-taken samples for human papillomavirus testing: a cross-sectional study in older women</style></title><secondary-title><style face="normal" font="default" size="100%">British Journal of General Practice</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">e538-e545</style></pages><doi><style  face="normal" font="default" size="100%">10.3399/BJGP.2021.0708</style></doi><volume><style face="normal" font="default" size="100%">72</style></volume><issue><style face="normal" font="default" size="100%">721</style></issue><abstract><style  face="normal" font="default" size="100%">Background Cervical cancer incidence and mortality are high in women aged ≥65 years, despite the disease being preventable by screening. Speculum-based screening can become more uncomfortable after the menopause.Aim To examine test performance and acceptability of human papillomavirus (HPV) testing on clinician-collected vaginal samples without a speculum (non-speculum).Design and setting Cross-sectional study in 11 GP practices and four colposcopy clinics in London, UK, between August 2017 and January 2019.Method Non-speculum and conventional (speculum) samples were collected from women aged ≥50 years attending for a colposcopy (following a speculum HPV-positive screening result) or women aged ≥35 years (with confirmed cervical intraepithelial neoplasia (CIN) 2+), and women aged 50–64 years attending routine screening. Sensitivity to CIN2+ was assessed among women with confirmed CIN2+ (colposcopy). Specificity to HPV relative to speculum sampling and overall concordance was assessed among women with negative cytology (routine screening).Results The sensitivity of non-speculum sampling for detecting CIN2+ was 83.3% (95% confidence interval [CI] = 60.8 to 94.2) (n = 15/18). There was complete concordance among women with positive CIN2+ who had a speculum sample ≤91 days prior to the non-speculum sample (n = 12). Among 204 women with negative cytology, the specificity to HPV was 96.4% (95% CI = 92.7 to 98.5), with 96.6% concordant results (κ 72.4%). Seventy-one percent (n = 120/170) of women preferred a non-speculum sample for their next screen.Conclusion HPV testing on non-speculum clinician-taken samples is a viable approach that warrants further exploration in larger studies. Overall test performance was broadly comparable with that of self-sampling.</style></abstract></record></records></xml>