PT - JOURNAL ARTICLE AU - Annie Jeffery AU - Cini Bhanu AU - Kate Walters AU - Ian C. K. Wong AU - David Osborn AU - Joseph F. Hayes TI - Polypharmacy and Antidepressant Acceptability in Comorbid Depression and Type 2 Diabetes AID - 10.3399/BJGP.2022.0295 DP - 2022 Oct 31 TA - British Journal of General Practice PG - BJGP.2022.0295 4099 - http://bjgp.org/content/early/2022/10/31/BJGP.2022.0295.short 4100 - http://bjgp.org/content/early/2022/10/31/BJGP.2022.0295.full AB - BACKGROUND: Polypharmacy may increase the risk of drug interactions, side-effects and poor adherence. However, the impact of polypharmacy on antidepressant acceptability in individuals with type 2 diabetes (T2DM) is unknown. AIM: In adults with T2DM, to investigate the association between the number of prescribed medications and: i) early antidepressant discontinuation (<32 weeks); ii) switching antidepressant agents. DESIGN: Cohort study using UK primary care data from the years 2000-2018. METHODS: We used cox regression with penalised B-splines to describe the association between the number of concurrently prescribed medications at the time of starting antidepressant treatment, and each of our outcomes. RESULTS: We identified 73,808 individuals with comorbid depression and T2DM starting antidepressant treatment for the first time. The median number of concurrent medications prescribed was 7. Within 32 weeks, 44.26% of participants discontinued antidepressant treatment altogether, and 11.75% of participants switched antidepressant agents. We found an inverse relationship between the number of concurrent medications and discontinuing antidepressant treatment altogether. The median number of 7 concurrent medications was associated with a 65.06% decrease early antidepressant discontinuation HR 0.45, 95% CIs 0.37-0.55). We found no evidence of an association, in our main analysis, between the number of concurrent medications and switching antidepressant agents. CONCLUSIONS: Early discontinuation of antidepressants is common in adults with T2DM. However, individuals with higher levels of concurrent polypharmacy may be more adherent to treatment. These are likely to represent individuals with worse physical/mental health. Individuals with lower levels of concurrent polypharmacy may benefit from adherence support.