RT Journal Article SR Electronic T1 Medical treatment for heavy menstrual bleeding in primary care: 10-year data from the ECLIPSE trial JF British Journal of General Practice JO Br J Gen Pract FD British Journal of General Practice SP e857 OP e864 DO 10.3399/BJGP.2022.0260 VO 72 IS 725 A1 Joe Kai A1 Brittany Dutton A1 Yana Vinogradova A1 Nicholas Hilken A1 Janesh Gupta A1 Jane Daniels YR 2022 UL http://bjgp.org/content/72/725/e857.abstract AB Background Heavy menstrual bleeding (HMB) is a common problem that can significantly affect women’s lives. There is a lack of evidence on long-term outcomes after seeking treatment.Aim To assess continuation rates of medical treatments and rates of surgery in women 10 years after initial management for HMB in primary care.Design and setting This was a prospective observational cohort study.Method Women with HMB who participated in the ECLIPSE primary care trial (ISRCTN86566246) completed questionnaires 10 years after randomisation to the levonorgestrel-releasing intrauterine system (LNG-IUS) or other usual medical treatments (oral tranexamic acid, mefenamic acid, combined oestrogen–progestogen; or progesterone alone). Outcomes were rates of surgery, medical treatments, and quality of life using the 36-item Short-Form Health Survey (SF-36) and EuroQoL EQ-5D.Results The responding cohort of 206 women was demographically and clinically representative of the original trial population. Mean age at baseline was 41.9 years (SD 4.9) and 53.7 years (SD 5.1) at follow-up. Over the 10-year follow-up, 60 of 206 (29.1%) women had surgery (hysterectomy n = 34, 16.5%; endometrial ablation n = 26, 12.6%). Between 5 and 10 years, 89 women (43.2%) ceased all medical treatments and 88 (42.7%) used LNG-IUS alone or in combination with other treatments. Fifty-six women (27.2%) were using LNG-IUS at 10 years. There were improvements over time in quality-of-life scores, with no evidence of differences in these or other outcomes between the two groups.Conclusion Medical treatments for women with HMB can be successfully initiated in primary care, with low rates of surgery and improvement in quality of life observed a decade later.