@article {Tonkin-Crinee164, author = {Sarah Tonkin-Crine and Monsey McLeod and Aleksandra J Borek and Anne Campbell and Philip Anyanwu and C{\'e}ire Costelloe and Michael Moore and Benedict Hayhoe and Koen B Pouwels and Laurence SJ Roope and Liz Morrell and Susan Hopkins and Christopher C Butler and Ann Sarah Walker}, editor = {,}, title = {Implementing antibiotic stewardship in high-prescribing English general practices: a mixed-methods study}, volume = {73}, number = {728}, pages = {e164--e175}, year = {2023}, doi = {10.3399/BJGP.2022.0298}, publisher = {Royal College of General Practitioners}, abstract = {Background Trials have identified antimicrobial stewardship (AMS) strategies that effectively reduce antibiotic use in primary care. However, many are not commonly used in England. The authors co-developed an implementation intervention to improve use of three AMS strategies: enhanced communication strategies, delayed prescriptions, and point-of-care C-reactive protein tests (POC-CRPTs).Aim To investigate the use of the intervention in high-prescribing practices and its effect on antibiotic prescribing.Design and setting Nine high-prescribing practices had access to the intervention for 12 months from November 2019. This was primarily delivered remotely via a website with practices required to identify an {\textquoteleft}antibiotic champion{\textquoteright}.Method Routinely collected prescribing data were compared between the intervention and the control practices. Intervention use was assessed through monitoring. Surveys and interviews were conducted with professionals to capture experiences of using the intervention.Results There was no evidence that the intervention affected prescribing. Engagement with intervention materials differed substantially between practices and depended on individual champions{\textquoteright} preconceptions of strategies and the opportunity to conduct implementation tasks. Champions in five practices initiated changes to encourage use of at least one AMS strategy, mostly POC-CRPTs; one practice chose all three. POC-CRPTs was used more when allocated to one person.Conclusion Clinicians need detailed information on exactly how to adopt AMS strategies. Remote, one-sided provision of AMS strategies is unlikely to change prescribing; initial clinician engagement and understanding needs to be monitored to avoid misunderstanding and suboptimal use.}, issn = {0960-1643}, URL = {https://bjgp.org/content/73/728/e164}, eprint = {https://bjgp.org/content/73/728/e164.full.pdf}, journal = {British Journal of General Practice} }