TY - JOUR T1 - Trimethoprim and co-trimoxazole in the treatment of acute urinary tract infections: patient compliance and efficacy JF - The Journal of the Royal College of General Practitioners JO - J R Coll Gen Pract SP - 274 LP - 280 VL - 31 IS - 226 AU - D. A. Andrewes AU - P. J. Chuter AU - M. J. Dawson AU - B. W. Eden AU - R. M. A. Moore AU - D. S. Freestone AU - C. A. Morris Y1 - 1981/05/01 UR - http://bjgp.org/content/31/226/274.abstract N2 - Patient compliance and drug efficacy and side-effects were compared in two groups of patients with symptoms of acute lower urinary tract infections. One group was treated with trimethoprim, one tablet (300 mg) once a day, and the other with co-trimoxazole, two tablets (160 mg trimethoprim, 800 mg sulphamethoxazole) twice a day; both treatments were prescribed for seven days. Patient compliance was significantly greater with trimethoprim: corrected percentage compliance rates were 97·5 per cent for trimethoprim and 79·1 per cent for co-trimoxazole (p<0·05). Trimethoprim and co-trimoxazole were of equivalent effectiveness in the control of symptoms. Side-effects were more frequent with co-trimoxazole, but the difference was not significant. ER -