PT  - JOURNAL ARTICLE
AU  - Frank de Wolf
AU  - Joep M.A. Lange
AU  - Margreet Bakker
AU  - Steven Tjong-A-Hung
AU  - Christa Hooykaas
AU  - Roel Coutinho
AU  - Jan van der Noordaa
AU  - Japp Goudsmit
TI  - Influenza-like syndrome in homosexual men: a prospective diagnostic study
DP  - 1988 Oct 01
TA  - The Journal of the Royal College of General Practitioners
PG  - 443--446
VI  - 38
IP  - 315
4099  - http://bjgp.org/content/38/315/443.short
4100  - http://bjgp.org/content/38/315/443.full
SO  - J R Coll Gen Pract1988 Oct 01; 38
AB  - In the course of a prospective study of the prevalence and incidence of infection with the human immunodeficiency virus (HIV) and risk factors for the acquired immune deficiency syndrome among 961 homosexual men, 97 initially HIV antibody seronegative men reported a febrile period lasting at least three days. In 60 of these men serological evidence for an infection was found: influenza A or B virus (17 men), HIV (14), Epstein-Barr virus (seven), parainfluenza virus type I, 11 or Ill (five), hepatitis A virus (three), cytomegalovirus (three), adenovirus (two), respiratory syncytial virus (two), hepatitis B virus (one) and Toxoplasma gondii (one). Combined infections were found in five men. A total of 17 men seroconverted for HIV antibody. The clinical symptoms of acute HIV infection closely resembled those of influenza A or B infection. Skin rashes also occurred frequently in men with HIV infection. HIV antibody seroconversion gives rise to a number of different symptoms and primary HIV infection should be included in the differential diagnosis of prolonged febrile illness in those at risk of HIV infection.