RT Journal Article
SR Electronic
T1 Treatment for hypertension interrupted by placebo: the response of patients with high and low general health questionnaire scores
JF The Journal of the Royal College of General Practitioners
JO J R Coll Gen Pract
FD British Journal of General Practice
SP 411
OP 412
VO 36
IS 290
A1 Albert Jacob
YR 1986
UL http://bjgp.org/content/36/290/411.abstract
AB A study is described in which established treatment for hypertension was interrupted by placebo as part of a change to an alternative treatment. The patients involved were divided into two groups according to their score on the general health questionnaire. All the patients showed an increase in diastolic pressure after the placebo phase of the change-over but the increase was greater for patients with a high score on the general health questionnaire than it was for patients with a low score. For the patients with a high score the diastolic pressure approximated to the level recorded when the diagnosis was first made, but for patients with a low score it was considerably lower than this initial reading. The implication of this finding for the design of `changeover' studies is discussed.