PT  - JOURNAL ARTICLE
AU  - E L Teare
AU  - J C Rawes
AU  - P Chakraverty
AU  - N D Noah
AU  - D Webster
AU  - T Corcoran
AU  - J Oxford
TI  - Failure of influenza vaccine to prevent two successive outbreaks of influenza A H1N1 in a school community.
DP  - 1990 Jan 01
TA  - British Journal of General Practice
PG  - 10--12
VI  - 40
IP  - 330
4099  - http://bjgp.org/content/40/330/10.short
4100  - http://bjgp.org/content/40/330/10.full
SO  - Br J Gen Pract1990 Jan 01; 40
AB  - Forty nine of the 149 boys (33%) at a preparatory school fell ill at the beginning of the autumn term 1986 with symptoms of influenza. One hundred and eighty two of the 470 pupils (39%) in the senior part of the same school had similar symptoms of influenza at the beginning of the spring term 1987. A new variant of influenza A H1N1 virus was isolated from both outbreaks and shown to be antigenically similar to A/Taiwan/1/86. The attack rate among pupils who had previously received trivalent influenza vaccine containing A/Chile/1/83 H1N1 antigen was not significantly different from the rate among those who had never been vaccinated. It is concluded that annual vaccination of all boarding school pupils may be inappropriate.