Main outcomes at 12 months.
| Intervention group (n = 73) | Control group (n = 66) | Relative risk (95% CI) | |
|---|---|---|---|
| Complete withdrawal (%) | 33 (45.2) | 6 (9.1) | 4.97 (2.2 to 11.1) |
| Reduce dose>50% (%) | 16 (21.9) | 11 (16.7) | |
| Persist (%) | 22 (30.1) | 47 (71.3) | |
| Dropouts (%) | 2 (2.7) | 2 (3) | |