Table 2

Symptom scores, short acting β2-agonist use, compliance and inhaler technique by off-label prescribing characteristics.

Children with licensed prescribing (%)Off-label prescription (%)χ2 test for trenda (P-value)
Total number of children16 1131050
Nighttime symptom scoreb
0 — None8959 (55.6)403 (38.4)
1 — 1–2 per month2510 (15.6)202 (19.2)126.705
2 — 1–2 per week2377 (14.8)196 (18.7)(<0.001)
3 — Daily2267 (14.1)249 (23.7)
Daytime symptom scoreb
0 — None6649 (41.3)301 (28.7)
1 — 1–2 per month3382 (21.0)208 (19.8)105.346
2 — 1–2 per week3236 (20.1)239 (22.8)(<0.001)
3 — Daily2846 (17.7)302 (28.8)
Activity symptom scoreb
0 — Rarely6925 (43.0)347 (33.0)
1 — Sport5919 (36.7)361 (34.4)87.082
2 — Active play2876 (17.8)293 (27.9)(<0.001)
3 — Walking on flat393 (2.4)49 (4.7)
Daily short acting β2-agonist useb
09536 (59.2)467 (44.5)
12014 (12.5)132 (12.6)93.105
22319 (14.4)221 (21.0)(<0.001)
>32244 (13.9)230 (21.9)
Poor compliance as assessed by the reviewer3200 (19.9)208 (19.8)1.518 (0.218)
Poor inhaler technique as observed at the review1735 (10.8)109 (10.4)0.116 (0.733)
  • a Degrees of freedom = 1.

  • b Significantly higher for patients who received an off-label prescription.