Table 1

Random effects meta-analysis of efficacy of topical antibiotics versus placebo in improving early (days 2–5) clinical remission.

Study or sub-categoryTreatment n/NControl n/NRR (random) 95% CIWeight %RR (random) 95% CI
Gigliotti 198421/19849/32Embedded Image6.182.20 (1.19 to 4.06)
Miller 1992126/143101/14149.311.23 (1.09 to 1.39)
Rose 2005123/163107/16344.521.15 (1.00 to 1.32)
Total (95% CI)340336100.001.24 (1.05 to 1.45)
Total events: 270 (treatment), 217 (control)
Test for heterogeneity:χ2 = 4.33, degrees of freedom = 2 (P = 0.12), l2 = 53.8%
Test for overall effect: Z = 2.61 (P = 0.009)
  • n = number of subjects in remission. N = number of subjects tested. RR = relative risk.