Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the original Dutch osteoporosis guidelines in 345 women.
| Cut-off | Criteriaa | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPVb, % (95% CI) | NPVb, % (95% CI) |
|---|---|---|---|---|---|
| 1 | WHO | 88 (77–99) | 40 (35–46) | 14 (9–18) | 97 (95–99) |
| Dutch | 83 (68–98) | 39 (34–45) | 9 (5–13) | 97 (95–99) | |
| 2 | WHO | 63 (47–80) | 67 (62–73) | 17 (10–24) | 95 (91–99) |
| Dutch | 50 (30–70) | 65 (60–71) | 10 (5–15) | 95 (91–99) | |
| 3 | WHO | 36 (20–35) | 88 (84–91) | 24 (12–35) | 93 (86–100) |
| Dutch | 29 (11–47) | 83 (79–88) | 14 (4–23) | 93 (86–100) | |
| 4 | WHO | 21 (7–35) | 90 (87–93) | 18 (6–31) | 92 (83–100) |
| Dutch | 20 (10–37) | 90 (86–93) | 13 (3–24) | 94 (86–102) | |
↵a WHO-criteria: DXA outcome is always based on T-scores. Dutch-criteria: DXA outcome is based on T-scores if age <70 years and on Z-scores of age ≥70 years.