Online Table 4

Characteristics of cases and matched controls and odds ratios for pneumonia for a number of diseases currently and potentially considered as risk factors for pneumococcal disease, all patients and patients aged 5–64 years.

Cases, n (%)Controls, n (%)Unadjusted OR (95% CI)Adjusteda OR (95% CI)
All patients (17 172 cases and 71 399 controls)
Conditions from current and new risk factor lists
 No current or new risk factors8338 (48.6)47385 (66.4)1.001.00
 Current risk factors only5198 (30.3)15028 (21.1)2.48 (2.37 to 2.59)2.33 (2.23 to 2.44)
 New risk factors only940 (5.5)3029 (4.2)2.51 (2.31 to 2.72)2.44 (2.24 to 2.65)
 Current and new risk factors2696 (15.7)5957 (8.3)3.80 (3.57 to 4.04)3.59 (3.38 to 3.82)
Conditions from current risk factor list
 Any current risk factor7894 (46.0)20985 (29.4)2.43 (2.34 to 2.53)2.29 (2.20 to 2.39)
 One condition5878 (34.2)17431 (24.4)2.18 (2.09 to 2.27)2.08 (1.99 to 2.17)
 Two conditions1680 (9.8)3142 (4.4)3.93 (3.66 to 4.21)3.63 (3.38 to 3.90)
 Three or more conditions336 (2.0)411 (0.6)6.12 (5.26 to 7.12)5.64 (4.84 to 6.58)
Conditions from current and new risk factor lists
 Any risk factor8834 (51.4)24014 (33.6)2.71 (2.60 to 2.82)2.56 (2.45 to 2.68)
 One condition4736 (27.6)15280 (21.4)2.26 (2.16 to 2.36)2.16 (2.06 to 2.26)
 Two conditions2786 (16.2)6669 (9.3)3.57 (3.37 to 3.79)3.37 (3.17 to 3.59)
 Three or more conditions1312 (7.6)2064 (2.9)5.85 (5.39 to 6.36)5.50 (5.05 to 5.98)
Patients aged 5–64 years (6108 cases and 23–383 controls)
Conditions from current and new risk factor lists
 No current or new risk factors3807 (62.3)18487 (79.1)1.001.00
 Current risk factors only1794 (29.4)3974 (17.0)2.30 (2.15 to 2.47)1.96 (1.82 to 2.11)
 New risk factors only166 (2.7)376 (1.6)2.49 (2.05 to 3.02)2.32 (1.91 to 2.82)
 Current and new risk factors341 (5.6)546 (2.3)3.65 (3.15 to 4.24)3.14 (2.69 to 3.66)
Conditions from current risk factor list
 Any current risk factor2135 (35.0)4520 (19.3)2.36 (2.21 to 2.52)2.01 (1.87 to 2.15)
 One condition1868 (30.6)4175 (17.9)2.23 (2.09 to 2.38)1.94 (1.80 to 2.09)
 Two conditions229 (3.75)311 (1.33)4.10 (3.42 to 4.92)3.05 (2.52 to 3.70)
 Three or more conditions38 (0.62)34 (0.15)6.83 (4.22 to 11.0)5.25 (3.21 to 8.58)
Conditions from current and new risk factor lists
 Any risk factor2301 (37.7)4896 (20.9)2.44 (2.29 to 2.61)2.10 (1.96 to 2.24)
 One condition1735 (28.4)4041 (17.3)2.20 (2.05 to 2.36)1.93 (1.80 to 2.08)
 Two conditions468 (7.7)756 (3.2)3.64 (3.20 to 4.13)3.01 (2.63 to 3.44)
 Three or more conditions98 (1.6)99 (0.4)6.45 (4.79 to 8.67)5.14 (3.79 to 6.97)
  • a All models include smoking status, Townsend score in quintiles, use of influenza vaccine in last 12 months, use of pneumococcal vaccine in last 5 years (1–14 days, 2–52 weeks, 12–48 months, 49–60 months), number of years of medical records data (5, 6, 7, 8, 9, ≥10). OR = odds ratio.