Parameter | Value/calculation | Source |
---|---|---|
Ethnic composition of the antenatal population | North European = 298/1454 | Dormandy et al, 20102 |
South or South East Asian = 420/1454 | ||
African/Caribbean = 357/1454 | ||
South European = 280/1454 | ||
Other = 61/1454 | ||
Mixed = 38/1454 | ||
Inter-ethnic unions 200310 | P = 0.0373 | Office for National Statistics, |
Mendelian recessive inheritance | If both parents are carriers: | Zeuner et al, 19994 |
P = 0.25 (child inherits both traits) | ||
P = 0.50 (child inherits one trait) | ||
P = 0.25 (child inherits no trait) | ||
If one parent is a carrier: | ||
P = 0.50 (child inherits one trait) | ||
P = 0.50 (child inherits no trait) | ||
Declared father's paternity | Declared father is not the biological father, P = 0.037 | Bellis et al, 200511 |
Failure to screen eligible women | Midwife = 117/441 | Dormandy et al, 20102 |
Primary care parallel = 106/677 | ||
Primary care sequential = 109/590 | ||
Declared father accepts screening | Father is tested when maternal | Dormandy et al, 20102 |
result is positive: Midwife = 10/20 | ||
Primary care parallel = 20/47 | ||
Primary care sequential = 14/24 | ||
Father is tested when maternal result is negative: Primary care parallel = 32/524 | ||
Woman accepts PND | As in Zeuner et al, 19994 | Zeuner et al, 19994 |
PND-inducedmiscarriage | P = 0.015 | Zeuner et al, 19994 |
Woman accepts TOP | Thalassaemia: P = 0.95 | Zeuner et al, 19994 |
Sickle cell disease: P = 0.70 | ||
Failure of fetus to reach term | P = 0.14 | Slattery and Morrison, 200212 |
PND = prenatal diagnosis. TOP = termination of pregnancy.