Unifactorial model, unadjusted for practice | Multifactorial model, adjusted for practice | |||||
---|---|---|---|---|---|---|
Predictor | HRa | 95% CI | P-value | HR | 95% CI | P-value |
Sex | ||||||
Female | — | — | ||||
Male | 1.07 | 1.03 to 1.1 | <0.001 | 1.06 | 1.02 to 1.09 | 0.001 |
Age, years | ||||||
<35b | — | — | ||||
36–65 | 0.76 | 0.73 to 0.78 | <0.001 | 0.77 | 0.74 to 0.79 | <0.001 |
>65 | 0.73 | 0.69 to 0.77 | <0.001 | 0.71 | 0.67 to 0.74 | <0.001 |
Deprivation quintile | ||||||
1 Low | — | — | ||||
2 | 1.09 | 1.03 to 1.16 | 0.006 | 1.07 | 1.00 to 1.14 | 0.043 |
3 | 1.18 | 1.12 to 1.25 | <0.001 | 1.12 | 1.05 to 1.19 | <0.001 |
4 | 1.19 | 1.12 to 1.25 | <0.001 | 1.17 | 1.09 to 1.24 | <0.001 |
5 High | 1.27 | 1.2 to 1.34 | <0.001 | 1.18 | 1.10 to 1.26 | <0.001 |
Comorbidityc | ||||||
No | — | — | ||||
Yes | 0.99 | 0.94 to 1.04 | 0.66 | —d | ||
Diagnosis coded | ||||||
No | — | — | ||||
Yes | 0.88 | 0.86 to 0.9 | <0.001 | 0.86 | 0.85 to 0.88 | <0.001 |
Previous treatment | ||||||
No | — | — | ||||
Yes | 0.94e | 0.91 to 0.97 | <0.001 | 0.92 | 0.89 to 0.95 | <0.001 |
↵a Hazard ratio (HR) = note that HR greater than one indicates a greater risk of discontinuing treatment at any given time point.
↵b When age <35 years compared to all other patients, hazard ratio = 1.33 (95% CI = 1.28 to 1.37).
↵c Comorbidity includes diabetes, coronary heart disease, and cancer; analysis was restricted to patients aged over 45 years.
↵d Comorbidity was omitted from the multifactorial model as unifactorial analysis was restricted to patients aged over 45 years.
↵e When restricted to patients aged over 35 years, hazard ratio = 0.98 (95% CI = 0.94 to 1.02), P-value = 0.4.