Table 1

Distribution of patients with at least one adverse drug event according to demographic variables, level of multimorbidity, and health services use

VariablePopulation (n = 79 089)Presence of at least one ADE (n = 692), n (%)95% CI of percentageP-value
Age, years
14–17205916 (0.78)0.40 to 1.16<0.001
18–3419 60087 (0.44)0.35 to 0.54
35–4412 45676 (0.61)0.47 to 0.75
45–5412 18892 (0.75)0.60 to 0.91
55–6412 347136 (1.1)0.92 to 1.29
65–69519374 (1.42)1.10 to 1.75
70–74497075 (1.51)1.17 to 1.85
75–79471767 (1.42)1.08 to 1.76
80–84320643 (1.34)0.94 to 1.74
≥85234826 (1.11)0.68 to 1.53
Sex
Male34 487224 (0.65)0.56 to 0.73<0.001
Female44 602468 (1.05)0.95 to 1.14
RUB
Healthy95520 (0)0<0.001
Low morbidity22 54243 (0.19)0.13 to 0.24
Moderate morbidity43 768460 (1.05)0.96 to 1.15
High morbidity3008158 (5.25)4.46 to 6.05
Very high morbidity21931 (14.16)9.53 to 18.78
Number of different specialties
045 297237 (0.52)0.46 to 0.59<0.001
1–332 966429 (1.3)1.18 to 1.42
4–681125 (3.08)1.89 to 4.27
>6151 (6.67)6.40 to 19.73
Number of family physician visits
0269828 (1.04)0.66 to 1.42<0.001
1–961 137352 (0.58)0.52 to 0.64
10–2012 171234 (1.92)1.68 to 2.17
21–30216956 (2.58)1.91 to 3.25
>3091422 (2.41)1.41 to 3.40
Polypharmacya
Yes19 666350 (1.78)1.59 to 1.96<0.001
No59 423342 (0.58)0.51 to 0.64
  • RUB = resource utilisation band.12

  • a Six or more different active compounds in at least 1 month.