Table 5.

Final multivariable models for each group

	Cases, n = 510		Controls, n = 6264

Symptom^a	Frequency	%	Frequency	%	OR	95% CI	Pvalue	LR	PPV, %	95% CI
A. Leukaemia/lymphoma
Bruising	30	5.9	1	0.02	138.1	17.6 to 1082.0	<0.001	368.5	0.53	0.07 to 3.91
Pallor	24	4.7	1	0.02	131.9	16.9 to 1031.9	<0.001	294.8	0.43	0.06 to 3.15
Lump mass swelling head and neck	20	3.9	1	0.02	59.2	7.1 to 492.6	<0.001	245.7	0.35	0.05 to 2.65
Fatigue	31	6.1	8	0.1	16.7	5.5 to 51.0	<0.001	47.6	0.07	0.03 to 0.15
Lymphadenopathy	60	11.8	17	0.3	17.9	8.8 to 36.4	<0.001	43.4	0.06	0.04 to 0.11
Lump mass swelling^b	21	4.1	7	0.1	30.1	5.8 to 156.0	<0.001	36.9	0.05	0.02 to 0.13
Bleeding	13	2.6	7	0.1	14.7	4.1 to 52.7	<0.001	22.8	0.03	0.01 to 0.08
Pain	17	3.3	11	0.2	5.1	1.8 to 14.6	0.003	19.0	0.03	0.01 to 0.06
Musculoskeletal symptoms	45	8.8	36	0.6	5.3	2.9 to 9.5	<0.001	15.4	0.02	0.01 to 0.03
Fever	36	7.1	76	1.2	2.4	1.3 to 4.5	0.007	5.8	0.01	0.01 to 0.01
Abdominal pain	24	4.7	56	0.9	3.0	1.6 to 5.7	<0.001	5.3	0.01	0.00 to 0.01
Three or more consultations	255	50	515	8.2	4.1	3.1 to 5.6	<0.001	6.1	0.01	0.01 to 0.01
B. Central nervous system tumour
Abnormal movement	32	11.9	3	0.1	2748.9	14.2 to 531 853.5	0.003	130.5	0.11	0.03 to 0.35
Visual symptoms	21	7.8	3	0.1	98.4	9.1 to 1067.5	<0.001	85.7	0.07	0.02 to 0.24
Vomiting	55	20.4	14	0.4	25.0	7.7 to 80.8	<0.001	48.1	0.04	0.02 to 0.07
Headache	58	21.5	18	0.5	23.0	8.3 to 63.5	<0.001	39.4	0.03	0.02 to 0.06
Pain	14	5.2	5	0.2	79.5	14.0 to 451.5	<0.001	34.3	0.03	0.01 to 0.08
Seizure^b	10	3.7	5	0.2	15.6	1.9 to 132.2	0.010	24.5	0.02	0.01 to 0.06
Three or more consultations	137	50.7	257	7.8	4.0	2.5 to 6.7	<0.001	6.5	0.01	0.00 to 0.01
C. Bone tumour/soft tissue sarcoma
Lump mass swelling^b	14	7.1	2	0.1	52.2	10.1 to 270.0	<0.001	86.69	0.03	0.01 to 0.14
Musculoskeletal symptoms	42	21.2	35	1.4	6.7	3.7 to 12.3	<0.001	14.86	0.01	0.00 to 0.01
Trauma	10	5.1	32	1.3	3.9	1.5 to 10.0	0.004	3.87	0.00	0.00 to 0.00
Three or more consultations	68	34.3	141	5.8	4.1	2.7 to 6.2	<0.001	5.97	0.00	0.00 to 0.00
D. Abdominal tumour
Bleeding	10	6.0	2	0.1	165.5	16.2	<0.001	56.14	0.03	0.01 to 0.12
Lump mass swelling^b	5	3.0	1	0.1	62.7	4.2	0.003	56.14	0.03	0.00 to 0.23
Weight loss^c	8	4.8	2	0.1	12.6	1.4	0.020	44.91	0.02	0.00 to 0.10
Abdominal pain	24	14.4	12	0.6	27.3	9.4	<0.001	22.46	0.01	0.01 to 0.02
Musculoskeletal symptoms	9	5.4	9	0.5	7.7	2.2	0.001	11.23	0.01	0.00 to 0.01
Childhood infection	13	7.8	40	2.1	3.8	1.6	0.003	3.65	0.00	0.00 to 0.00
Three or more consultations	81	48.5	224	12.0	3.6	2.2	<0.001	4.06	0.00	0.00 to 0.00

↵a Symptoms are ordered by PPV.
↵b Lump mass swelling below neck excluding abdomen.
↵c Has a P value below the threshold but is needed in the model based on the likelihood ratio test. LR = likelihood ratio. OR = odds ratio. PPV = positive predictive value.