Table 3.

Multivariable analysis of the features of childhood cancer, all cancers

	Cases, n = 1267		Controls, n = 15 318

Symptom^a	Frequency	%	Frequency	%	OR^b	95% CI	P-value	PPV %	95% CI
Pallor	29	2.29	3	0.02	83.7	18.0 to 390.5	<0.001	0.41	0.12 to 1.34
Lump mass swelling head and neck	28	2.21	4	0.03	16.9	5.2 to 54.9	<0.001	0.30	0.10 to 0.84
Lump mass swelling^c	42	3.31	16	0.1	21.8	9.6 to 49.7	<0.001	0.11	0.06 to 0.20
Lymphadenopathy	69	5.45	33	0.22	10.1	5.9 to 17.4	<0.001	0.09	0.06 to 0,13
Abnormal movement	49	3.87	26	0.17	16.4	7.8 to 34.9	<0.001	0.08	0.04 to 0.14
Bruising	33	2.6	18	0.12	12.3	5.5 to 27.8	<0.001	0.08	0.05 to 0.13
Fatigue	42	3.31	24	0.16	7.7	3.8 to 15.8	<0.001	0.07	0.04 to 0.12
Bleeding	28	2.21	21	0.14	9.9	4.9 to 20.2	<0.001	0.06	0.03 to 0.10
Headache	73	5.76	55	0.36	6.1	3.8 to 9.9	<0.001	0.06	0.04 to 0.08
Visual	28	2.21	21	0.14	10.4	4.4 to 24.3	<0.001	0.06	0.03 to 0.10
Pain	42	3.31	41	0.27	7.3	4.0 to 13.4	<0.001	0.04	0.03 to 0.06
Musculoskeletal symptoms	107	8.45	102	0.67	5.3	3.6 to 7.7	<0.001	0.04	0.03 to 0.07

↵a Symptoms are ordered by positive predictive value.
↵b Adjusted for all the symptoms appearing in the table.
↵c Lump mass swelling below neck excluding abdomen. OR = odds ratio. PPV = positive predictive value.