Table 1

Predefined cut-off values top 10 target drugs with truncated guideline advice

Therapeutic group	Drug name	Cut-off values, ml/min	Guideline advice
Blood-glucose-lowering drugs	Metformin	30–50	Initial dose 2 × 500 mg
		<30	Contraindicated

	Glimepiride	10–50	Initial dose 50%

Cardiac glycosides (digoxin)	Digoxin	10–50	Initial dose 50%

Low-ceiling diuretics, thiazides	Hydrochlorothiazide	30–50	Initial dose 12.5 mg
		<30	Contraindicated

High-ceiling diuretics	Furosemide	10–30	Dose higher

Potassium-sparing diuretics	Spironolactone	10–50	Monitor potassium

	Amiloride	30–50	Monitor potassium
		<30	Contraindicated

Diuretics combinations	Triamterene	30–50	Dose 50%, monitor potassium
		<30	Contraindicated

	Epitizide	<30	Contraindicated

Beta-blockers	Sotalol	30–50	Max dose 160 mg/day
		10–30	Max dose 80 mg/day

Angiotensin-converting enzyme inhibitors	Enalapril	30–50	Initial dose 5 mg
		10–30	Initial dose 2.5 mg