Baseline predictors of change in modelled 10-year cardiovascular risk score (UKPDS risk engine version 3) in the ADDITION-Cambridge cohort
| Variable | n (%) | Beta coefficienta | (95% CI) | P-value |
|---|---|---|---|---|
| Sex | ||||
| Female | 2.36 (40) | — | — | — |
| Male | 3.61 (60) | 3.84 | 2.28 to 5.39 | <0.01 |
| Age at diagnosis, continuous variable | 0.18 | 0.09 to 0.27 | <0.01 | |
| Education, age finished, years | ||||
| <16 | 2.71 (45) | — | — | — |
| 16–18 | 246 (41) | –0.61 | –1.92 to 0.71 | 0.36 |
| >18 | 71 (12) | –0.62 | –2.64 to 1.40 | 0.54 |
| Smoking | ||||
| Never | 2.38 (40) | — | — | — |
| Former | 260 (44) | 1.29 | –0.20 to 2.78 | 0.09 |
| Current | 99 (17) | 0.95 | –0.39 to 2.28 | 0.16 |
| BMI, baseline | 0.02 | –0.08 to 0.12 | 0.68 | |
| Waist circumference, continuous variable | 0.05 | 0.01 to 0.09 | 0.01 | |
| Ethnicity | ||||
| White | 578 (97) | — | — | — |
| Asian | 17 (3) | –3.20 | –5.01 to –1.40 | <0.001 |
| Social class | ||||
| Professional | 31 (5) | — | — | — |
| Managerial and technical | 204 (34) | –0.32 | –3.09 to 2.45 | 0.82 |
| Skilled occupation: non-manual | 93 (16) | –2.94 | –5.93 to 0.05 | 0.05 |
| Skilled occupation: manual | 152 (25) | –0.01 | –3.15 to 3.14 | 1.00 |
| Partly skilled | 68 (11) | –0.91 | –3.55 to 1.72 | 0.49 |
| Unskilled | 38 (6) | –1.18 | –4.67 to 2.32 | 0.50 |
| Civil status | ||||
| Unmarried | 460 (77) | — | — | — |
| Married | 36 (6) | –2.01 | –4.74 to 0.72 | 0.15 |
| Divorced/separated | 54 (9) | –0.77 | –2.62 to 1.09 | 0.41 |
| Widow/widower | 45 (8) | –0.94 | –1.66 to 3.54 | 0.47 |
BMI = body mass index. CVD = cardiovascular disease. CVD risk change = follow-up CVD risk — baseline CVD risk.
↵a Beta-coefficients denote the association between baseline predictors and CVD risk change adjusted for baseline CVD risk, treatment group, and clustering by practice. Numbers do not add up to total due to missing data.