Table 1

Prevalence and performance of individual 7PCL items in detecting (A) clinically significant lesions and (B) melanoma

7PCL Item	Item Prevalence	Clinically significant			Melanoma
7PCL Item	Item Prevalence	Sensitivity	Specificity	Test of association^a	Sensitivity	Specificity	Test of association^b
1. Change in size of lesion	48.3% (693/1436)	55.1% (124/225)	53.0% (642/1211)	0.030	72.2% (26/36)	52.4% (733/1400)	0.004
2. Irregular pigmentation	48.9% (702/1436)	71.1% (160/225)	55.2% (669/1211)	<0.001	86.1% (31/36)	52.1% (729/1400)	<0.001
3. Irregular border	34.3% (492/1436)	63.6% (143/225)	71.2% (862/1211)	<0.001	69.4% (25/36)	66.6% (933/1400)	<0.001
4. Inflammation	9.2% (132/1436)	11.6% (26/225)	91.2% (1105/1211)	0.180	16.7% (6/36)	91.0% (1274/1400)	0.150
5. Itch or altered sensation	27.6% (397/1436)	26.7% (60/225)	72.2% (874/1211)	0.720	25.0% (9/36)	72.3% (1012/1400)	0.850
6. Lesion larger than others	48.4% (695/1436)	56.4% (127/225)	53.1% (643/1211)	0.010	75.0% (27/36)	52.3% (732/1400)	0.001
7. Oozing/crusting of lesion	10.0% (144/1436)	11.6% (26/225)	90.3% (1093/1211)	0.410	19.4% (7/36)	90.2% (1263/1400)	0.080

↵a P-values are from the χ² test of association between item and reference standard.
↵b P-values are from Fisher’s exact test of association between item and reference standard