Table 4

Mean changes from baseline to follow-up time points in selected domains of the SCNS-P&C and SF-12 component scores, adjusted for baseline patient performance status (AKPS 60–70 and 10–50)

AKPS 60–70						AKPS 10–50

	Treatment group Mean change (SD)			Absolute difference between groups LSM (95%CI)	P-value	Treatment group Mean change (SD)		Absolute difference between groups LSM (95% CI)	P-value

Characteristic	Follow-up time	Control	Intervention			Control	Intervention
SCNS-P&C Psychology and emotional needs^a	1 Months	−0.8 (7.8)	−0.2 (6.5)	1.12 (−1.22 to 3.46)	0.344	−0.6 (6.7)	−1.6 (7.5)	0.55 (−3.31 to 4.42)	0.775
	3 Months	−0.4 (8.3)	−1.9 (7.1)	0.54 (−2.08 to 3.15)	0.686	−3.7 (7.3)	0.1 (7.6)	4.61 (0.40 to 8.82)	0.033^b
	6 Months	−2.1 (9.8)	−1.6 (8.2)	1.26 (−2.11 to 4.62)	0.461	−4.9 (11.3)	−0.9 (8.0)	4.17 (−1.91 to 10.25)	0.171

SF-12 Physical component score^c	1 Months	−0.7 (6.6)	−0.6 (8.3)	0.26 (−2.22 to 2.74)	0.837	2.0 (8.4)	−3.7 (8.1)	5.21 (0.32 to 10.09)	0.037^b
	3 Months	−1.4 (7.8)	−1.1 (7.8)	0.44 (−2.35 to 3.23)	0.753	4.5 (8.8)	−1.8 (7.1)	4.82 (−0.53 to 10.17)	0.076^b
	6 Months	−0.5 (7.4)	−0.4 (8.2)	0.22 (−2.74 to 3.19)	0.881	1.2 (10.6)	−2.2 (10.9)	1.96 (−5.89 to 9.81)	0.614

SF-12 Mental component score^c	1 Months	−0.9 (9.7)	0.9 (8.3)	0.95 (−1.95 to 3.84)	0.520	−2.1 (10.3)	2.3 (9.1)	2.12 (−3.82 to 8.07)	0.476
	3 Months	−1.5 (9.4)	3.2 (8.0)	3.54 (0.52 to 6.56)	0.022^d	0.7 (8.9)	2.9 (11.1)	1.78 (−4.25 to 7.81)	0.553
	6 Months	−0.0 (12.3)	1.5 (10.6)	0.28 (−3.94 to 4.51)	0.894	3.0 (10.3)	3.8 (10.9)	1.53 (−6.03 to 9.09)	0.682

↵a SCNS-P&C domain scores normalised to range of 0–100.
↵b Favours control.
↵c SF12 component score range from 0–100.
↵d Favours intervention.