Table 1.

Sensitivities and specificities (%) of anti-nuclear antibody (ANA) for rheumatic conditions5

DiseaseSensitivitySpecificityStaining patternComments
SLE9357Homogeneous
Speckled
Nucleolar
Anti-histone is an additional antibody that has very high sensitivity and specificity for drug-induced lupus
A rim pattern may also be seen in SLE
Systemic sclerosis/scleroderma8554Centromere (limited form)
Speckled (diffuse form)
Nucleolar
Polymyositis/Dermatomyositis6163Speckled
Sjögren’s syndrome4452Speckled
Juvenile chronic arthritis5739Homogeneous
Rheumatoid arthritis4156Homogeneous
  • The typical ANA staining patterns seen under immunofluorescence microscopy are also provided.

  • SLE = systemic lupus erythematosus.