Table 4.

Unadjusted and adjusted regression analysis of factors associated with stroke and death in patients at moderate-high risk of stroke at baseline

	Stroke		Death

	OR (95% CI)	P-value	OR (95% CI)	P-value
Unadjusted analysis
Age	1.10 (1.08 to 1.12)	<0.001	1.11 (1.09 to 1.13)	<0.001
Female	1.65 (1.27 to 2.15)	<0.001	1.70 (1.28 to 2.27)	<0.001
Heart failure	1.86 (1.41 to 2.46)	<0.001	2.09 (1.56 to 2.81)	<0.001
Hypertension	1.09 (0.82 to 1.45)	0.541	1.10 (0.81 to 1.49)	0.554
Diabetes	1.47 (1.10 to 1.96)	0.010	1.43 (1.04 to 1.95)	0.027
Previous stroke	1.68 (1.25 to 2.26)	0.001	0.95 (0.66 to 1.35)	0.769
Vascular disease	2.88 (2.17 to 3.83)	<0.001	3.20 (2.37 to 4.33)	<0.001
CHADS₂ score	1.48 (1.34 to 1.63)	<0.001	1.36 (1.23 to 1.51)	<0.001
CHA₂DS₂-VASc score	1.51 (1.38 to 1.64)	<0.001	1.44 (1.31 to 1.57)	<0.001
Use of oral anticoagulation	0.53 (0.40 to 0.69)	<0.001	0.43 (0.32 to 0.58)	<0.001
Use of antiplatelet agents	1.14 (0.88 to 1.49)	0.318	0.99 (0.74 to 1.32)	0.951

Adjusted analysis ^a
Use of oral anticoagulation	0.60 (0.45 to 0.81)	0.001	0.54 (0.38 to 0.75)	<0.001
Use of antiplatelet agents	0.86 (0.64 to 1.14)	0.286	0.69 (0.50 to 0.94)	0.020

OR = odds ratio.
↵a Predictive value of antithrombotic agents after adjustment for stroke risk factors.