Clinical prediction rule | SI/referral among High-risk, % | SI/referral among Low-risk, % | Sensitivity % (95%CI) | Specificity % (95% CI) | LR+ (95% CI) | LR– (95% CI) |
---|---|---|---|---|---|---|
1. Van den Bruel et al 6 | ||||||
Derivation-population (n = 3981) | 6 | 0.03 | 97 (83 to 100) | 89 (88 to 90) | 8.4 (7.6 to 9.4) | 0.04 (0.01 to 0.2) |
GPC-population (n = 9794) | 13 | 6 | 54 (50 to 57) | 68 (67 to 69) | 1.7 (1.6 to 1.8) | 0.7 (0.6 to 0.7) |
2. Thompson et al 18 | ||||||
Derivation-population (n = 527) | 54 | 31 | 80 (75 to 85) | 39 (34 to 44) | 1.3 (1.2 to 1.5) | 0.5 (0.4 to 0.7) |
GPC-population (n = 9590) | 22 | 4 | 50 (47 to 54) | 86 (85 to 87) | 3.6 (3.3 to 3.9) | 0.6 (0.5 to 0.6) |
3. Pantell et al 19 | ||||||
Derivation-population (n = 3066) | 3 | 0.4 | 94 (84 to 98) | 35 (33 to 37) | 1.4 (1.3 to 1.5) | 0.2 (0.1 to 0.5) |
GPC-population (n = 240) | 78 | 38 | 42 (33 to 53) | 89 (81 to 94) | 3.7 (2.1 to 6.6) | 0.7 (0.5 to 0.8) |
GPC = GP cooperative. LR– = negative likelihood ratio. LR+ = positive likelihood ratio. N = number of contacts. SI = serious infection.