Sensitivity and specificity for most useful individual clinical items
| Number with data (% missing) | Sensitivity (95% CI) | Specificity (95% CI) | ||
|---|---|---|---|---|
| No dementia (n= 191) | Dementia (n= 59) | |||
| Any memory difficulty (subject) | 187 (0.02) | 56 (0.05) | 91.1 (80.4 to 97.0) | 19.8 (14.3 to 26.2) |
| Any memory difficulty (informant) | 157 (0.18) | 53 (0.10) | 83.0 (70.2 to 91.9) | 31.2 (24.1 to 39.1) |
| Forget where left things (subject) | 188 (0.02) | 56 (0.05) | 91.1 (80.4 to 97.0) | 31.9 (25.3 to 39.1) |
| Forget where left things (informant) | 159 (0.17) | 53 (0.10) | 81.1 (68.0 to 90.6) | 40.9 (33.2 to 49.0) |
| Forget what going to do (informant) | 148 (0.23) | 51 (0.14) | 66.7 (52.1 to 79.2) | 56.8 (48.4 to 64.9) |
| Forget names (subject) | 189 (0.01) | 56 (0.05) | 62.5 (48.6 to 75.1) | 66.7 (59.5 to 73.3) |
| Forget names (informant) | 161 (0.16) | 53 (0.10) | 62.3 (47.9 to 75.2) | 65.2 (57.3 to 72.5) |
| Repeat question (subject) | 186 (0.03) | 55 (0.07) | 65.5 (51.4 to 77.8) | 63.3 (56.0 to 70.2) |
| Repeat question (informant) | 159 (0.17) | 53 (0.10) | 66.0 (51.7 to 78.5) | 63.5 (55.5 to 71.0) |
| Wrong word (subject) | 189 (0.01) | 56 (0.05) | 51.8 (38.0 to 65.3) | 68.3 (61.1 to 74.8) |
| Wrong word (informant) | 161 (0.16) | 53 (0.10) | 50.9 (36.8 to 64.9) | 70.8 (63.1 to 77.7) |
| Examination findings | ||||
| Any gait disturbance | 184 (0.04) | 56 (0.05) | 42.9 (29.7 to 56.8) | 91.3 (86.3 to 95.0) |
| Any primitive reflexes | 166 (0.13) | 46 (0.22) | 45.7 (30.9 to 61.0) | 77.1 (70.0 to 83.3) |
| Pout | 183 (0.04) | 51 (0.14) | 21.6 (11.3 to 35.3) | 93.4 (88.8 to 96.6) |
| IQCODE (informant). Compared with 10 years ago, how is this person at: | ||||
| Family and friends | 133 (0.30) | 44 (0.25) | 75.0 (59.7 to 86.8) | 70.7 (62.2 to 78.3) |
| Recall recent events | 163 (0.15) | 54 (0.08) | 79.6 (66.5 to 89.4) | 65.6 (57.8 to 72.9) |
| Recall conversations | 164 (0.14) | 55 (0.07) | 78.2 (65.0 to 88.2) | 53.7 (45.7 to 61.5) |
| Recall own address | 161 (0.16) | 52 (0.12) | 50.0 (35.8 to 64.2) | 91.3 (85.8 to 95.2) |
| Recall day | 162 (0.15) | 55 (0.07) | 69.1 (55.2 to 80.9) | 78.4 (71.3 to 84.5) |
| Recall where kept | 159 (0.17) | 52 (0.12) | 73.1 (59.0 to 84.4) | 77.4 (70.1 to 83.6) |
| Recall different place | 161 (0.16) | 51 (0.14) | 86.3 (73.7 to 94.3) | 50.9 (42.9 to 58.9) |
| Work appliances | 156 (0.18) | 49 (0.17) | 53.1 (38.3 to 67.5) | 91.0 (85.4 to 95.0) |
| Learn new gadget | 157 (0.18) | 52 (0.12) | 86.5 (74.2 to 94.4) | 62.4 (54.4 to 70.0) |
| Learn in general | 162 (0.15) | 55 (0.07) | 81.8 (69.1 to 90.9) | 68.5 (60.8 to 75.6) |
| Follow story | 159 (0.17) | 52 (0.12) | 65.4 (50.9 to 78.0) | 79.3 (72.1 to 85.3) |
| Decisions | 157 (0.18) | 48 (0.19) | 60.4 (45.3 to 74.2) | 89.2 (83.2 to 93.6) |
| Shopping money | 156 (0.18) | 48 (0.19) | 50.0 (35.2 to 64.8) | 94.2 (89.3 to 97.3) |
| Personal finance | 135 (0.29) | 42 (0.29) | 66.7 (50.5 to 80.4) | 93.3 (87.7 to 96.9) |
| Everyday maths | 130 (0.32) | 43 (0.27) | 65.1 (49.1 to 79.0) | 90.8 (84.4 to 95.1) |
| Reasoning | 164 (0.14) | 55 (0.07) | 50.9 (37.1 to 64.7) | 95.1 (90.6 to 97.9) |
| Everyday activities (asked of subject and informant, present if either identified) | ||||
| Any problems with daily activities | 184 (0.04) | 55 (0.07) | 54.6 (40.6 to 68.0) | 75.5 (68.7 to 81.6) |
| Dressing | 172 (0.10) | 54 (0.08) | 31.5 (19.5 to 45.6) | 90.1 (84.7 to 94.1) |
| Toileting | 172 (0.10) | 55 (0.07) | 29.1 (17.6 to 42.9) | 91.9 (86.7 to 95.5) |
| Hygiene | 170 (0.11) | 55 (0.07) | 32.7 (20.7 to 46.7) | 95.3 (90.9 to 98.0) |
| Physical symptoms (informant) | ||||
| Any physical symptoms | 181 (0.05) | 52 (0.12) | 63.5 (49.0 to 76.4) | 75.7 (68.8 to 81.8) |
| Urinary incontinence | 184 (0.04) | 55 (0.07) | 47.3 (33.7 to 61.2) | 92.9 (88.2 to 96.2) |
| Falls | 186 (0.03) | 55 (0.07) | 49.1 (35.4 to 62.9) | 79.6 (73.1 to 85.1) |
| General functioning report (informant) | ||||
| Often muddled | 104 (0.46) | 49 (0.17) | 53.1 (38.3 to 67.5) | 94.2 (87.9 to 97.9) |
| Sometimes muddled | 102 (0.47) | 50 (0.15) | 66.0 (51.2 to 78.8) | 78.4 (69.2 to 86.0) |
| Planning | 103 (0.46) | 46 (0.22) | 76.1 (61.2 to 87.4) | 82.5 (73.8 to 89.3) |
| Concentrating | 103 (0.46) | 47 (0.20) | 80.9 (66.7 to 90.9) | 57.3 (47.2 to 67.0) |
| Talk less | 103 (0.46) | 49 (0.17) | 55.1 (40.2 to 69.3) | 78.6 (69.5 to 86.1) |
| Repeat words | 102 (0.47) | 50 (0.15) | 48.0 (33.7 to 62.6) | 81.4 (72.5 to 88.4) |
| No insight | 101 (0.47) | 47 (0.20) | 61.7 (46.4 to 75.5) | 82.2 (73.3 to 89.1) |
| Personality/emotion/behaviour (informant) | ||||
| Any personality change | 164 (0.14) | 52 (0.12) | 71.2 (56.9 to 82.9) | 56.7 (48.8 to 64.4) |
| Labile | 155 (0.19) | 50 (0.15) | 42.0 (28.2 to 56.8) | 87.1 (80.8 to 91.9) |
| Unmotivated | 152 (0.20) | 48 (0.19) | 37.5 (24.0 to 52.7) | 83.6 (76.7 to 89.1) |
| Disinhibited | 152 (0.20) | 48 (0.19) | 27.1 (15.3 to 41.9) | 94.7 (89.9 to 97.7) |
| Sleep disturbed | 152 (0.20) | 48 (0.19) | 45.8 (31.4 to 60.8) | 79.0 (71.6 to 85.1) |
| Aggressive | 153 (0.20) | 49 (0.17) | 40.8 (27.0 to 55.8) | 89.5 (83.6 to 93.9) |
| Narrowed preoccupations | 152 (0.20) | 48 (0.19) | 37.5 (24.0 to 52.7) | 92.8 (87.4 to 96.3) |
| Mental rigidity | 145 (0.24) | 49 (0.17) | 24.5 (13.3 to 38.9) | 92.4 (86.8 to 96.2) |
| Any functioning problems | 164 (0.14) | 53 (0.10) | 88.7 (77.0 to 95.7) | 40.2 (32.7 to 48.2) |
| Symptom fluctuation (any) | 146 (0.24) | 49 (0.17) | 42.9 (28.8 to 57.8) | 78.1 (70.5 to 84.5) |
| Day to day | 140 (0.27) | 49 (0.17) | 42.9 (28.8 to 57.8) | 82.9 (75.6 to 88.7) |
| Age >75 years | 191 (0.00) | 59 (0.00) | 72.9 (59.7 to 83.6) | 45.6 (38.3 to 52.9) |