Association between diagnostic variables and pertussis in patients presenting with acute cough in primary care
| All patients | Pertussis present | OR (95% CI) | Missing | |||
|---|---|---|---|---|---|---|
| N= 3074, n (%) | N= 93, n (%) | Univariate | Multivariate | P-valuea | N (%) | |
| Mean age, years (SD) | 50 (17) | 47 (16) | 0.99 (0.98 to 1.00) | 0.99 (0.98 to 1.00) | 0.125 | 0 (0.0) |
| Male sex | 1233 (40) | 40 (43) | 1.13 (0.75 to 1.72) | NA | – | 0 (0.0) |
| Current smoker | 860 (28) | 25 (27) | 0.96 (0.60 to 1.53) | NA | – | 3 (0.1) |
| Comorbidity (pulmonary, cardiac, DM)b | 847 (28) | 24 (26) | 0.91 (0.57 to 1.46) | NA | – | 5 (0.2) |
| Cough duration >2 weeks before index consultation | 525 (17) | 25 (27) | 1.79 (1.12 to 2.86) | 1.89 (1.17 to 3.07) | 0.010 | 45 (1.5) |
| Fever | 1071 (35) | 26 (28) | 0.72 (0.45 to 1.14) | 0.71 (0.44 to 1.14) | 0.153 | 5 (0.2) |
| Disturbed sleep | 1935 (63) | 68 (73) | 1.62 (1.02 to 2.57) | 1.61 (1.00 to 2.60) | 0.052 | 5 (0.2) |
| Wheeze | 1309 (43) | 35 (38) | 0.81 (0.53 to 1.23) | 0.79 (0.51 to 1.22) | 0.281 | 5 (0.2) |
| Interference with normal activities or work | 1937 (63) | 63 (68) | 1.24 (0.80 to 1.92) | 1.28 (0.80 to 2.05) | 0.311 | 3 (0.1) |
Data are presented as n (%), unless mentioned otherwise. DM = diabetes mellitus. NA = not analysed. OR = odds ratio. SD = standard deviation.
↵a For multivariate analysis.
↵b Pulmonary comorbidity = history of COPD, asthma, or other lung disease. Cardiac comorbidity = history of heart failure, ischaemic heart disease, or other heart disease. P< 0.05 significant.