IAD (mmHg) | Number of events | Unadjusted HR (95% CI) | P-value | Adjusted HRa (95% CI) | P-value | P-value for change in goodness of fit if IAD term removed (LR) |
---|---|---|---|---|---|---|
All cases | ||||||
All deaths | ||||||
≥5 | 120/1337 versus 242/2013 | 1.33 (1.07 to 1.66) | 0.011 | 1.44 (1.15 to 1.79) | 0.001 | 0.001 |
≥10 | 209/2070 versus 153/1280 | 1.14 (0.84 to 1.56) | 0.398 | 1.18 (0.95 to 1.46) | 0.130 | 0.131 |
≥15 | 299/2797 versus 63/553 | 1.02 (0.78 to 1.34) | 0.871 | 1.06 (0.80 to 1.40) | 0.675 | 0.676 |
Cardiovascular deaths | ||||||
≥5 | 24/1337 versus 70/2013 | 1.92 (1.21 to 3.05) | 0.006 | 1.91 (1.19 to 3.07) | 0.008 | 0.005 |
≥10 | 46/2070 versus 48/1280 | 1.62 (1.08 to 2.43) | 0.019 | 1.49 (0.98 to 2.27) | 0.060 | 0.061 |
≥15 | 78/2797 versus 16/553 | 1.00 (0.58 to 1.71) | 0.987 | 0.87 (0.50 to 1.53) | 0.634 | 0.629 |
Hypertensive cases | ||||||
All deaths | ||||||
≥5 | 27/316 versus 59/448 | 1.54 (0.98 to 2.43) | 0.064 | 1.67 (1.05 to 2.66) | 0.031 | 0.026 |
≥10 | 42/465 versus 44/299 | 1.59 (1.04 to 2.43) | 0.031 | 1.63 (1.06 to 2.50) | 0.026 | 0.026 |
≥15 | 67/620 versus 19/144 | 1.18 (0.71 to 1.97) | 0.517 | 1.18 (0.70 to 1.99) | 0.541 | 0.546 |
Cardiovascular deaths | ||||||
≥5 | 6/316 versus 20/448 | 2.34 (0.94 to 5.83) | 0.068 | 2.63 (0.97 to 7.02) | 0.053 | 0.036 |
≥10 | 9/465 versus 17/299 | 2.87 (1.28 to 6.44) | 0.011 | 2.96 (1.27 to 6.88) | 0.012 | 0.008 |
≥15 | 22/620 versus 4/144 | 0.76 (0.27 to 2.20) | 0.759 | 0.77 (0.26 to 2.26) | 0.633 | 0.623 |
↵a Model adjusted for age, sex, Scottish index of multiple deprivation, smoking status, cholesterol, systolic blood pressure, pulse pressure, ankle-brachial index, presence of diabetes, and allocation to aspirin or placebo. HR = hazard ratio. IAD = inter-arm difference. LR = likelihood ratio.