Antibiotic prescribing strategy | Poorer global symptomatic outcome, n (%) | Interaction term (95% CI), P-value | Univariate risk ratio (95% CI), P-value | Risk ratio controlling for baseline severity and clustering (95% CI), P-value | Risk ratio controlling for propensity score (95% CI), P-value | Risk ratio controlling for propensity score in imputed dataset (95% CI), P-value |
---|---|---|---|---|---|---|

None (reference)n= 33 | 23 (69.7) | 1.00 | 1.00 | 1.00 | 1.00 | |

Immediaten= 374 | 207 (55.3) | 0.88 (0.68 to 1.14), P = 0.345 | 0.79 (0.62 to 1.01), P = 0.063 | 0.79 (0.62 to 1.00), P = 0.051 | 0.79 (0.63 to 1.00), P = 0.046 | 0.82 (0.65 to 1.03), P = 0.097 |

Delayedn= 43 | 21 (48.8) | 0.83 (0.55 to 1.23), P = 0.349 | 0.70 (0.48 to 1.02), P = 0.066 | 0.72 (0.49 to 1.06), P = 0.096 | 0.64 (0.45 to 0.92), P = 0.015 | 0.65 (0.45 to 0.94), P = 0.021 |

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*a**Centor score: 1 point for each of tonsillar exudates, swollen tender anterior cervical nodes, lack of a cough, and history of fever.*