The odds of having a kidney function too low for the drug with increased age compared with those aged 65–74 years, using eGFR, creatinine clearance (Cockcroft–Gault) calculated using actual body weight, and using ideal body weight
| Drug | Kidney function calculation | 65–74 years | 75–84 years | ≥85 years | ||
|---|---|---|---|---|---|---|
| Odds ratio | Odds ratio | 95% CI | Odds ratio | 95% CI | ||
| Alendronic acid | eGFR | 1 | 1.96 | 1.08 to 3.56 | 5.49 | 3.07 to 9.81 |
| CrCl-AW | 1 | 5.11 | 3.59 to 7.26 | 24.12 | 16.93 to 34.36 | |
| CrCl-IBW | 1 | 6.28 | 4.61 to 8.57 | 26.95 | 19.56 to 37.13 | |
| Metformin | eGFR | 1 | 2.26 | 0.80 to 6.35 | 6.15 | 1.87 to 6.35 |
| CrCl-AW | 1 | 5.90 | 3.20 to 10.88 | 48.64 | 26.70 to 88.61 | |
| CrCl-IBW | 1 | 6.52 | 4.36 to 9.75 | 36.93 | 24.33 to 58.05 | |
| Simvastatin >10 mg | eGFR | 1 | 2.45 | 1.89 to 3.17 | 4.98 | 3.71 to 6.70 |
| CrCl-AW | 1 | 5.03 | 4.06 to 6.23 | 30.64 | 24.73 to 37.95 | |
| CrCl-IBW | 1 | 5.47 | 4.60 to 6.50 | 27.43 | 22.93 to 32.80 | |
| Gabapentin/pregabalin | eGFR | 1 | 2.73 | 1.27 to 5.89 | 4.28 | 1.78 to 10.26 |
| CrCl-AW | 1 | 2.97 | 1.55 to 5.72 | 9.96 | 5.25 to 18.88 | |
| CrCl-IBW | 1 | 1.83 | 1.21 to 2.79 | 3.33 | 2.03 to 5.45 | |
| Nitrofurantoin | eGFR | 1 | 3.03 | 4.20 to 4.18 | 5.24 | 3.78 to 7.27 |
| CrCl-AW | 1 | 6.79 | 5.16 to 8.92 | 41.33 | 30.87 to 55.36 | |
| CrCl-IBW | 1 | 5.64 | 4.58 to 6.95 | 29.23 | 22.75 to 37.56 | |
| Thiazides | eGFR | 1 | 2.19 | 1.42 to 3.37 | 5.29 | 3.32 to 8.43 |
| CrCl-AW | 1 | 5.60 | 3.96 to 7.93 | 49.67 | 35.52 to 69.44 | |
| CrCl-IBW | 1 | 6.68 | 5.07 to 8.80 | 45.50 | 34.52 to 59.98 | |
| NSAIDs | eGFR | 1 | 4.20 | 1.05 to 16.84 | 3.68 | 0.38 to 35.57 |
| CrCl-AW | 1 | 3.50 | 1.52 to 8.03 | 43.93 | 20.31 to 95.03 | |
| CrCl-IBW | 1 | 9.73 | 4.50 to 21.03 | 80.76 | 36.94 to 176.55 | |
| ACEIs/ARBs | eGFR | 1 | 1.81 | 1.49 to 2.21 | 3.84 | 3.09 to 4.78 |
| CrCl-AW | 1 | 4.73 | 3.98 to 5.61 | 29.01 | 24.27 to 34.38 | |
| CrCl-IBW | 1 | 4.95 | 4.33 to 5.65 | 25.22 | 21.99 to 28.93 | |
ACEIs = angiotensin-converting enzyme inhibitors. ARBs = angiotensin II receptor blockers. CrCl-AW = creatinine clearance (Cockcroft-Gault) calculated using actual body weight. CrCl-IBW = creatinine clearance (Cockcroft-Gault) calculated using ideal body weight. eGFR = estimated glomerular filtration rate. NSAIDs = non-steroidal anti-inflammatory drugs.