Factors associated with hazard of death (any cause)
| Patient characteristic | Any-cause death (Na = 2108)b | Unadjusted HR (95% CI) | Adjustedc HR (95% CI) |
|---|---|---|---|
| Sex (N= 2108) | |||
| Female versus male | 886 | 0.57 (0.53 to 0.63) | 0.72 (0.64 to 0.81) |
| Age (N= 2108) | |||
| Mean, + 1 year (SD) | 72.8 (14.3) | 1.07 (1.06 to 1.07) | 1.06 (1.06 to 1.07) |
| Urban–rural (six-fold) (N= 2079) | |||
| 1 = Large urban area | 759 | 1 | 1 |
| 2 = Other urban area | 614 | 1.02 (0.92 to 1.13) | 0.95 (0.83 to 1.08) |
| 3 = Accessible small town | 187 | 0.98 (0.82 to 1.18) | 0.82 (0.64 to 1.04) |
| 4 = Remote small town | 104 | 1.27 (1.07 to 1.50) | 0.90 (0.79 to 1.02) |
| 5 = Accessible rural | 246 | 0.97 (0.82 to 1.15) | 1.02 (0.86 to 1.22) |
| 6 = Remote rural | 169 | 1.18 (0.99 to 1.39) | 1.03 (0.86 to 1.22) |
| Deprivation — SIMD quintiles (N= 2080) | |||
| 1 = most deprived | 336 | 1 | 1 |
| 2 | 410 | 0.95 (0.85 to 1.06) | 0.87 (0.77 to 0.98) |
| 3 | 451 | 0.89 (0.76 to 1.05) | 0.79 (0.67 to 0.92) |
| 4 | 428 | 0.76 (0.68 to 0.86) | 0.69 (0.63 to 0.77) |
| 5 = least deprived | 455 | 0.65 (0.57 to 0.75) | 0.56 (0.45 to 0.70) |
| Setting of excision (N= 2080) | |||
| Secondary care | 1950 | 1 | 1 |
| Primary care | 130 | 0.69 (0.55 to 0.86) | 0.90 (0.71 to 1.13) |
| Anatomical site (N= 2089) | |||
| Head and neck | 706 | 1 | 1 |
| Body | 598 | 0.55 (0.51 to 0.61) | 1.08 (0.92 to 1.28) |
| Upper limb | 324 | 0.47 (0.43 to 0.51) | 0.85 (0.69 to 1.05) |
| Groin and lower limb | 461 | 0.50 (0.46 to 0.54) | 1.02 (0.82 to 1.27) |
| Melanoma subtype (N= 1795) | |||
| Superficial spreading | 565 | 1 | 1 |
| Nodular | 375 | 4.61 (4.04 to 5.28) | 1.75 (1.46 to 2.10) |
| Lentigo | 309 | 2.43 (2.07 to 2.87) | 1.14 (0.91 to 1.42) |
| Acral | 76 | 3.29 (2.58 to 4.18) | 1.54 (1.33 to 1.79) |
| Others | 470 | 2.96 (2.59 to 3.38) | 1.43 (1.26 to 1.62) |
| Breslow thickness, mm (N= 2108) | |||
| Median (IQR) | 0.8 (0.5–1.4) | 1.13 (1.11 to 1.15) | 1.09 (1.06 to 1.12) |
| Metastasis at presentation (N= 2108) | |||
| Yes | 296 | 5.83 (4.52 to 7.51) | 3.50 (2.60 to 4.70) |
| Charlson comorbidity index (N= 2080) | |||
| 0 | 1678 | 1 | 1 |
| 1 | 192 | 3.30 (2.73 to 4.00) | 1.89 (1.61 to 2.2) |
| 2 | 157 | 2.63 (2.17 to 3.19) | 1.53 (1.32 to 1.79) |
| ≥3 | 53 | 6.40 (5.11 to 8.01) | 2.93 (2.33 to 3.68) |
↵a Unless otherwise stated.
↵b Some data are missing in each row. The number available for analysis is presented individually in each row.
↵c Adjusted for sex, age, deprivation, setting of excision, anatomical site, melanoma subtype, Breslow thickness, metastasis at presentation, and Charlson index except where the variable itself is being examined. HR = hazards ratio. IQR = interquartile range. SD = standard deviation. SIMD = Scottish Index of Multiple Deprivation.