Not hospitalised | Hospitalised | Univariable analysis clustering by clinician | Multivariable analysis accounting for covariates where P<0.05 and clustering by clinician | Analysis stratified by propensity score and accounting for clustering by clinician | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | % | n | % | RR | 95% CI | P-valuea | RR | 95% CI | P-valuea | RR | 95% CI | P-valuea | |
No antibiotic | 5196/8255 | 62.9 | 40/65 | 61.5 | Ref | Ref | 0.53 (2 df) | Ref | Ref | 0.31 (2 df)b | Ref | Ref | 0.44 (2 df) |
Immediate | 2292/8255 | 27.8 | 21/65 | 32.3 | 1.19 | 0. 70 to 1.88 | 0.81 | 0.40 to 1.32 | 0.83 | 0.47 to 1.45 | |||
Delayed | 767/8255 | 9.3 | 4/65 | 6.2 | 0.68 | 0.24 to 1.88 | 0.62 | 0.22 to 1.66 | 0.70 | 0.26 to 1.90 |
↵a Overall P-value.
↵b Covariates included (<0.05): age<(2 years), current asthma, short<(3 days) illness duration prior to baseline, moderate/severe vomiting in the 24 hours before baseline, clinician-reported wheeze, high temperature (age-related cut-offs). df = degrees of freedom. Ref = reference. RR = risk ratio.